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Molecular mimicry between GQ1b ganglioside and lipopolysaccharides of Campylobacter jejuni isolated from patients with Fisher's syndrome
- Source :
- Annals of neurology. 36(5)
- Publication Year :
- 1994
-
Abstract
- We isolated Campylobacter jejuni from 2 patients with Fisher's syndrome subsequent to enteritis. Crude lipopolysaccharide fractions were extracted from the bacteria and separated by thin-layer chromatography. Monoclonal antibodies to GQ1b ganglioside (GMR13 and 7F5) reacted with both lipopolysaccharide fractions, indicating that the lipopolysaccharides bear the GQ1b epitope. This is the first report of molecular mimicry between neural tissue components and the antecedent infectious agents of Fisher's syndrome.
- Subjects :
- Lipopolysaccharides
Male
Lipopolysaccharide
Cerebellar Ataxia
medicine.drug_class
medicine.disease_cause
Monoclonal antibody
Campylobacter jejuni
Epitope
Enteritis
Microbiology
chemistry.chemical_compound
Epitopes
Gangliosides
Campylobacter Infections
medicine
Humans
Ophthalmoplegia
biology
Molecular Mimicry
Antibodies, Monoclonal
Syndrome
biology.organism_classification
medicine.disease
Molecular mimicry
Neurology
chemistry
Monoclonal
Immunology
biology.protein
Neurology (clinical)
Chromatography, Thin Layer
Antibody
Subjects
Details
- ISSN :
- 03645134
- Volume :
- 36
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Annals of neurology
- Accession number :
- edsair.doi.dedup.....d82cabecbd6920d20a00015e98f33188