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Effects of Electroacupuncture on PGC-1αExpression in Brown Adipose Tissue

Authors :
Yubin Zhang
Bin Xu
Tianyue Shan
Hui Wu
Zhenjue Wu
Hongyin Du
Cuisong Zhou
Source :
Evidence-based Complementary and Alternative Medicine : eCAM, Evidence-Based Complementary and Alternative Medicine, Vol 2013 (2013)
Publication Year :
2013
Publisher :
Hindawi Limited, 2013.

Abstract

The inducible coactivator PGC-1αplays master regulator in mitochondrial biogenesis and thermogenesis in brown adipose tissues (BATs). BAT is a natural antiobesity organ which dissipates chemical energy in the form of heat through specialized mitochondrial protein UCP-1. Eletroacupuncture (EA) has been widely used as an alternative treatment for obesity and its related disorders such as type 2 diabetes. The molecular mechanism of electroacupuncture on treatment of obesity is still unclear. We hypothesized that electroacupuncture induced PGC-1αexpression to increase the energy expenditure in BAT. Rats were randomly divided into control group and electroacupuncture treatment group. We investigated the effects of electroacupuncture at Zusanli (ST36) acupoint on the expressions of PGC-1αand its associated genes in the BAT of rats using real-time PCR and western blotting. We found that electroacupuncture effectively induces the expression of PGC-1αand UCP-1 by 4-fold and 5-fold in the BAT of rats, respectively. Our results indicated that the molecular mechanism of electroacupuncture for the treatment of obesity may be, or at least partially, through induction of both PGC-1αand UCP-1 expressions to increase energy expenditure in BAT.

Details

ISSN :
17414288 and 1741427X
Volume :
2013
Database :
OpenAIRE
Journal :
Evidence-Based Complementary and Alternative Medicine
Accession number :
edsair.doi.dedup.....d81c62595d4cec49c4098ac9e2f2ea9f