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Effects of Electroacupuncture on PGC-1αExpression in Brown Adipose Tissue
- Source :
- Evidence-based Complementary and Alternative Medicine : eCAM, Evidence-Based Complementary and Alternative Medicine, Vol 2013 (2013)
- Publication Year :
- 2013
- Publisher :
- Hindawi Limited, 2013.
-
Abstract
- The inducible coactivator PGC-1αplays master regulator in mitochondrial biogenesis and thermogenesis in brown adipose tissues (BATs). BAT is a natural antiobesity organ which dissipates chemical energy in the form of heat through specialized mitochondrial protein UCP-1. Eletroacupuncture (EA) has been widely used as an alternative treatment for obesity and its related disorders such as type 2 diabetes. The molecular mechanism of electroacupuncture on treatment of obesity is still unclear. We hypothesized that electroacupuncture induced PGC-1αexpression to increase the energy expenditure in BAT. Rats were randomly divided into control group and electroacupuncture treatment group. We investigated the effects of electroacupuncture at Zusanli (ST36) acupoint on the expressions of PGC-1αand its associated genes in the BAT of rats using real-time PCR and western blotting. We found that electroacupuncture effectively induces the expression of PGC-1αand UCP-1 by 4-fold and 5-fold in the BAT of rats, respectively. Our results indicated that the molecular mechanism of electroacupuncture for the treatment of obesity may be, or at least partially, through induction of both PGC-1αand UCP-1 expressions to increase energy expenditure in BAT.
- Subjects :
- medicine.medical_specialty
Pathology
Article Subject
business.industry
Electroacupuncture
medicine.medical_treatment
Adipose tissue
lcsh:Other systems of medicine
Zusanli
lcsh:RZ201-999
Blot
medicine.anatomical_structure
Endocrinology
Complementary and alternative medicine
Mitochondrial biogenesis
Internal medicine
Brown adipose tissue
Coactivator
medicine
business
Thermogenesis
Research Article
Subjects
Details
- ISSN :
- 17414288 and 1741427X
- Volume :
- 2013
- Database :
- OpenAIRE
- Journal :
- Evidence-Based Complementary and Alternative Medicine
- Accession number :
- edsair.doi.dedup.....d81c62595d4cec49c4098ac9e2f2ea9f