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Synthesis of N-substituted iminosugar derivatives and their immunosuppressive activities
- Source :
- Carbohydrate Research. 345:780-786
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- Several N-alkyl and hydroxyethyl-substituted iminosugar derivatives, including L-altro and D-galacto epimers, were synthesized and the effects of these synthetic iminosugars on proliferation of mouse splenocytes were evaluated in the MTT assay. The experimental data demonstrated that the N-alkylated D-galacto iminosugars showed better inhibitory activities than L-altro analogues, which might hold potential as immunosuppressive agents.
- Subjects :
- Male
Mice, Inbred BALB C
Magnetic Resonance Spectroscopy
Chemistry
Stereochemistry
Organic Chemistry
Iminosugar
Stereoisomerism
General Medicine
Biochemistry
Combinatorial chemistry
Imino Sugars
Analytical Chemistry
Mice
Structure-Activity Relationship
Animals
Structure–activity relationship
MTT assay
Epimer
Immunosuppressive Agents
Spleen
Cell Proliferation
Subjects
Details
- ISSN :
- 00086215
- Volume :
- 345
- Database :
- OpenAIRE
- Journal :
- Carbohydrate Research
- Accession number :
- edsair.doi.dedup.....d81430af504b04a581ed068addabfba6