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Relationships Between Telomere Length, Plasma Glucagon-like Peptide 1, and Insulin in Early-Life Stress–Exposed Nonhuman Primates
- Source :
- Biological Psychiatry Global Open Science, Vol 2, Iss 1, Pp 54-60 (2022)
- Publication Year :
- 2022
- Publisher :
- Elsevier, 2022.
-
Abstract
- Background: Early-life stress is associated with alterations in telomere length, a marker of accumulated stress and aging, and a risk factor for psychiatric disorders. Nonhuman primate maternal variable foraging demand (VFD) is a validated early-life stress model, resulting in anxiety- and depressive-like symptoms in offspring. Previous studies reported increased plasma glucagon-like peptide 1 (pGLP-1) along with insulin resistance in this model. We investigated whether VFD rearing related to adult telomere length and to these neuroendocrine markers. Methods: Adult leukocyte telomere length was measured in VFD-reared (12 males, 13 females) and non-VFD–reared (9 males, 26 females) bonnet macaques. Associations between adult telomere length and adolescent fasting pGLP-1 or insulin resistance in VFD-reared versus non-VFD–reared groups were examined using regression modeling, controlling for sex, weight, and age. Results: VFD subjects had relatively longer telomeres than non-VFD subjects (p = .017), and females relatively longer than males (p = .0004). Telomere length was positively associated with pGLP-1 (p = .0009) and with reduced insulin sensitivity (p < .0001) in both sexes, but not as a function of rearing group. Conclusions: Unexpectedly, VFD was associated with longer adult telomere length. Insulin resistance may lead to higher pGLP-1 levels in adolescence, which could protect telomere length in VFD offspring as adults. Associations between adult telomere length and adolescent insulin resistance and high pGLP-1 may reflect an adaptive, compensatory response after early-life stress exposure.
- Subjects :
- medicine.medical_specialty
Offspring
medicine.medical_treatment
Early life stress
RC435-571
Peptide
pGLP-1
Biology
Adversity
Insulin resistance
Internal medicine
medicine
Maltreatment
Insulin
Risk factor
Early-life stress
chemistry.chemical_classification
Adaptive calibration
Psychiatry
General Medicine
medicine.disease
Telomere
Endocrinology
chemistry
Anxiety
medicine.symptom
Subjects
Details
- Language :
- English
- ISSN :
- 26671743
- Volume :
- 2
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Biological Psychiatry Global Open Science
- Accession number :
- edsair.doi.dedup.....d80b90b42fcd3abb6e438444dac6d035