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Sirtuin 1: Endocan and Sestrin 2 in Different Biological Samples in Patients with Asthma. Does Severity Make the Difference?
- Source :
- Journal of Clinical Medicine, Volume 9, Issue 2, Journal of Clinical Medicine, Vol 9, Iss 2, p 473 (2020)
- Publication Year :
- 2020
-
Abstract
- Background: Sestrin 2, Endocan, and Sirtuin 1 are distinct molecules with some biologic actions associated with asthma pathophysiology. The aim of the present study was to determine the molecular level differences attributable to underlying asthma severity. Methods: We initially recruited 85 asthmatics with a wide spectrum of severity. All of the patients were optimally treated according to current guidelines. Demographics, test results of lung function, and treatment regimes of all patients were recorded. Sestrin 2, Endocan, and Sirtuin 1 were measured in different biological samples (sputum with two processing methods and serum). Results: A total of 60 patients (35 with severe asthma) were analyzed, since 25 patients failed to produce an adequate sample of sputum. Patients with severe asthma showed significantly higher values for Sestrin 2 [pg/mL], measured in both sputum supernatant and cell pellet, compared to those with mild to moderate asthma [9524 (5696, 12,373) vs. 7476 (4265, 9273) p = 0.029, and 23,748 (15,280, 32,742) vs. 10,084 (3349, 21,784), p = 0.008, respectively]. No other significant differences were observed. No significant associations were observed between biomarkers, inflammatory cells, and lung function. Conclusion: Sestrin 2 is increased in patients with severe asthma as part of a mechanism that may modify structural alterations through the imbalance between oxidative stress and antioxidant activity.
- Subjects :
- medicine.medical_specialty
lcsh:Medicine
severity
Inflammation
medicine.disease_cause
Gastroenterology
Article
03 medical and health sciences
0302 clinical medicine
Molecular level
Sirtuin 1
Internal medicine
medicine
In patient
Endocan
Sestrin 2
Asthma
biology
business.industry
lcsh:R
General Medicine
medicine.disease
Pathophysiology
respiratory tract diseases
030228 respiratory system
inflammation
030220 oncology & carcinogenesis
biology.protein
Sputum
medicine.symptom
business
Oxidative stress
Subjects
Details
- ISSN :
- 20770383
- Volume :
- 9
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of clinical medicine
- Accession number :
- edsair.doi.dedup.....d806f09ec97bac88cc0d006164b0ae49