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Cognitive Function in Pediatric Hypoplastic Left Heart Syndrome: Systematic Review and Meta-Analysis
- Source :
- J Pediatr Psychol
- Publication Year :
- 2019
- Publisher :
- Oxford University Press (OUP), 2019.
-
Abstract
- Objective Despite surgical palliation, children with hypoplastic left heart syndrome (HLHS) have compromised cardiac functioning and increased risk for cognitive deficits. We quantitatively reviewed the empirical data from this literature. Methods The present meta-analysis included 13 studies reporting cognitive function for children with HLHS between the ages of 2 years and 6 months and 17 years that used standardized assessments of Full Scale IQ (FSIQ), Verbal IQ (VIQ), and Performance IQ (PIQ). Differences in cognitive function were assessed relative to normative data, and we examined sample mean age and publication year as moderators. Results Large effects were found for FSIQ (g = −.87, 95% CI [−1.10, −.65], M = 86.88) and PIQ (g = −.89, 95% CI [−1.11, −.68], M = 86.56), and a medium effect was found for VIQ (g = −.61, 95% CI [−.84, −.38], M = 90.82). All models demonstrated significant heterogeneity. Meta-regression analyses of effect size via Hedges’ g on child age revealed a significant effect on FSIQ (coefficient = −.07, 95% CI [−.12, −.01], p < .01, R2 = .40) indicating a loss of 1.1 FSIQ points across studies with each increased year of mean sample age. Conclusions Deficits in FSIQ may reflect chronic brain injury or failure to make expected gains as children age. This review highlights the importance of early intervention in this population, and the need for longitudinal studies analyzing more specific domains of cognitive function and potential moderators.
- Subjects :
- Pediatrics
medicine.medical_specialty
Adolescent
Child age
Population
030204 cardiovascular system & hematology
Hypoplastic left heart syndrome
Systematic Reviews and Meta-Analyses
03 medical and health sciences
0302 clinical medicine
030225 pediatrics
Hypoplastic Left Heart Syndrome
Developmental and Educational Psychology
medicine
Humans
Cognitive Dysfunction
Child
education
Cognitive deficit
education.field_of_study
business.industry
Cognition
medicine.disease
Sample mean and sample covariance
Child, Preschool
Meta-analysis
Pediatrics, Perinatology and Child Health
Verbal iq
medicine.symptom
business
Subjects
Details
- ISSN :
- 1465735X and 01468693
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Journal of Pediatric Psychology
- Accession number :
- edsair.doi.dedup.....d7f2935b3fca20d5006ff6bd2dc474cd