A mechanical toy model linking cell-substrate adhesion to multiple cellular migratory responses

During cell migration, forces applied to a cell from its environment influence the motion. When the cell is placed on a substrate, such a force is provided by the cell-substrate adhesion. Modulation of adhesivity, often performed by the modulation of the substrate stiffness, tends to cause common responses for cell spreading, cell speed, persistence, and random motility coefficient. Although the reasons for the response of cell spreading and cell speed have been suggested, other responses are not well understood. In this study, we develop a simple toy model for cell migration driven by the relation of two forces: the adhesive force and the plasma membrane tension. The simplicity of the model allows us to perform the calculation not only numerically but also analytically, and the analysis provides formulas directly relating the adhesivity to cell spreading, persistence, and the random motility coefficient. Accordingly, the results offer a unified picture on the causal relations between those multiple cellular responses. In addition, cellular properties that would influence the migratory behavior are suggested.