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The Lipid-Bound Apolipoprotein A-I Cysteine Mutant (N74C) Inhibits the Activation of NF-κB, JNK and p38 in Endotoxemic Mice and RAW264.7 Cells
- Source :
- PLoS ONE, Vol 7, Iss 12, p e51327 (2012), PLoS ONE
- Publication Year :
- 2012
- Publisher :
- Public Library of Science (PLoS), 2012.
-
Abstract
- Our previous studies showed that recombinant high-density lipoprotein (rHDL) rHDL74 exhibited higher anti-inflammatory capabilities compared to wild-type rHDL (rHDLwt), while rHDL228 showed hyper-proinflammation. In this paper, we further investigated the potential mechanisms involved in their different inflammatory functions using two models: endotoxemic mice and the RAW264.7 inflammation model. Our results showed that 24 h after the injection of lipopolysaccharide (LPS), mice treated with rHDL74 had a significant decrease in plasma CRP (P
- Subjects :
- MAPK/ERK pathway
Mouse
Lipopolysaccharide
MAP Kinase Kinase 4
lcsh:Medicine
Signal transduction
ERK signaling cascade
p38 Mitogen-Activated Protein Kinases
Biochemistry
Mice
chemistry.chemical_compound
Molecular cell biology
lcsh:Science
Multidisciplinary
medicine.diagnostic_test
Chemistry
NF-kappa B
Signaling cascades
Animal Models
Signaling in Selected Disciplines
Lipids
medicine.symptom
Research Article
medicine.medical_specialty
Lipoproteins
CD14
p38 mitogen-activated protein kinases
Immunology
Inflammation
Immunological Signaling
Cell Line
Model Organisms
Western blot
Internal medicine
medicine
Animals
Cysteine
Biology
Apolipoprotein A-I
lcsh:R
Immunity
Proteins
NFKB1
Endotoxemia
Apolipoproteins
Endocrinology
lcsh:Q
Lipoprotein
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....d7ea869949f0d49a591ce4cc60242c2f