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A Cross-Sectional Pharmacoepidemiological Study of the Utilization Pattern of Pre-Anesthetic Medications in Major Surgical Procedures in a Tertiary Care Hospital
- Source :
- Cureus
- Publication Year :
- 2017
-
Abstract
- OBJECTIVE A study of the utilization pattern of pre-anesthetic medications in major surgical procedures. MATERIAL AND METHODS A cross-sectional, pharmacoepidemiological study was conducted among patients undergoing surgical procedures in routine or emergency conditions under general anesthesia. The utilization of pre-anesthetic medicines in all patients was reported. RESULTS A total of 110 patients (mean age - 42.36 years; 57.27% males) were enrolled. The major (>10%) indications for surgery were carcinoma/tumor - 25 (22.73%), perforation peritonitis - 20 (18.18%), and intestinal obstruction - 11 (10%). All patients received ranitidine plus metoclopramide. Injections of ondansetron, midazolam, pentazocin, anticholinergic agents, and fentanyl were used in 103 (93.64%), 103 (93.64%), 92 (83.64%), 84 (76.36%), and 23 (20.91%) patients, respectively. The dosage of ondansetron was 4 mg in 95 patients (86.36%), while 89.09% patients received 1 mg of midazolam. In 86 patients (78.18%), pentazocine was used in a 15 mg dose. Among the anticholinergic agents, glycopyrrolate was used in 76 patients (69.09%). Glycopyrrolate was used in a 0.2 mg dose in 74 patients (97.37%). The major indications for the use of fentanyl were carcinoma - 8 (34.8%), perforation peritonitis - 4 (17.4%), and surgery for intestinal obstruction - 3 (13%). CONCLUSION The administration of ondansetron, midazolam, and pentazocin is very common (>80% patients) as pre-anesthetic medication. Glycopyrrolate was the preferred anticholinergic agent. In cancer patients, the use of fentanyl is common.
- Subjects :
- medicine.medical_specialty
business.industry
medicine.drug_class
Perforation (oil well)
General Engineering
Anticholinergic agents
Fentanyl
surgical procedures
Ranitidine
Ondansetron
03 medical and health sciences
0302 clinical medicine
030202 anesthesiology
Anesthesiology
Anesthesia
Emergency medicine
medicine
Anticholinergic
pre-anesthetic medications
Midazolam
030212 general & internal medicine
business
drug utilization
Glycopyrrolate
medicine.drug
Subjects
Details
- ISSN :
- 21688184
- Volume :
- 9
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Cureus
- Accession number :
- edsair.doi.dedup.....d7e365bd90d54b2510ab9e17d34edbb0