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A rational approach to the control of sedation in intensive care unit patients based on closed-loop control
- Source :
- European Journal of Anaesthesiology. 16:678-687
- Publication Year :
- 1999
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1999.
-
Abstract
- Optimal control of long-term sedation during therapy in the intensive care unit is difficult to achieve in a number of patients when based on commonly used clinical sedation scores alone. We therefore used the median frequency of the EEG power spectrum as a quantitative measure for closed-loop administration of propofol in 21 artificially ventilated patients (nine trauma, 12 non-trauma). The EEG setpoint was correlated with a clinical sedation score and defined such, that mechanical ventilation was tolerated. The sedative therapy was given for 31 +/- 30 h. Non-trauma patients required sedation with an EEG median frequency between 2 and 3 Hz (propofol consumption: 1.4 +/- 0.8 mg kg-1 h-1) and sedation seemed to follow some circadian patterns, whereas trauma patients needed significantly deeper sedation (EEG median frequency: 1-2 Hz; propofol consumption: 2.6 +/- 0.8 mg kg-1 h-1). We conclude that the EEG closed-loop system could safely and reliably administer propofol to maintain a predetermined level of sedation for patients in intensive care unit over a protracted time.
- Subjects :
- Adult
Male
Artificial ventilation
Adolescent
Critical Care
medicine.drug_class
medicine.medical_treatment
Sedation
Conscious Sedation
Electroencephalography
law.invention
law
Intensive care
medicine
Humans
Hypnotics and Sedatives
Propofol
APACHE
Aged
Postoperative Care
Mechanical ventilation
medicine.diagnostic_test
Multiple Trauma
business.industry
Middle Aged
Respiration, Artificial
Intensive care unit
Intensive Care Units
Anesthesiology and Pain Medicine
Sedative
Anesthesia
Female
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 02650215
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- European Journal of Anaesthesiology
- Accession number :
- edsair.doi.dedup.....d7e2044bf0c16337febc98c966407279
- Full Text :
- https://doi.org/10.1097/00003643-199910000-00004