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Molecular Genetics of the Psychosis Phenotype
- Source :
- ResearcherID
- Publication Year :
- 2012
- Publisher :
- SAGE Publications, 2012.
-
Abstract
- Objective: Relative to recent successes in elucidating the genetic mechanisms associated with complex diseases, including macular degeneration, diabetes mellitus, type 2, heart disease, and cancer, molecular genetic approaches to psychiatric illness have met with more limited success. While factors such as small allelic effects, allelic heterogeneity, and variation in population substructure have received considerable attention in attempt to explain the paucity of significant results in psychiatric genetics, significantly less focus has been directed toward phenotypic factors. Method: Data derived from molecular genetic studies of the psychosis phenotype in patients with a range of psychiatric illnesses are reviewed. Results: Available data suggest that genes do not respect the boundaries of the current diagnostic system but may confer risk for symptom-based phenotypic variation that traverses those boundaries. Conclusions: Molecular genetic studies offer convincing evidence for a relation between genetic variation and symptom-based phenotypic variation within psychiatric illness. These data may provide novel insights into the pathophysiology of schizophrenia and other related disorders. The exploration of relations between genetic variation and symptom variation that traverses traditional diagnostic boundaries may ultimately lead to more refined classification systems that more closely reflect the genetic etiology of psychiatric illness.
- Subjects :
- medicine.medical_specialty
Psychosis
Bipolar Disorder
Genotype
Heart disease
Genetic Linkage
Neuregulin-1
Population
Nerve Tissue Proteins
Catechol O-Methyltransferase
Bioinformatics
Article
Diagnosis, Differential
Molecular genetics
Diseases in Twins
medicine
Humans
Genetic Predisposition to Disease
Allele
education
Psychiatry
Genetic Association Studies
Psychiatric genetics
Psychiatric Status Rating Scales
Depressive Disorder, Major
education.field_of_study
Dysbindin
Intracellular Signaling Peptides and Proteins
Genetic Variation
Macular degeneration
medicine.disease
Diagnostic and Statistical Manual of Mental Disorders
Psychiatry and Mental health
Phenotype
Psychotic Disorders
Dystrophin-Associated Proteins
Schizophrenia
Schizophrenic Psychology
Allelic heterogeneity
Carrier Proteins
Psychology
Subjects
Details
- ISSN :
- 14970015 and 07067437
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- The Canadian Journal of Psychiatry
- Accession number :
- edsair.doi.dedup.....d7e0d5301fac2a9a1ad623d77c6f350b