Back to Search
Start Over
Macromolecular Viral Entry Inhibitors as Broad-Spectrum First-Line Antivirals with Activity against SARS-CoV-2
- Source :
- Advanced Science, Advanced Science, 2022, 9 (20), pp.2201378. ⟨10.1002/advs.202201378⟩, Groß, R, Dias Loiola, L M, Issmail, L, Uhlig, N, Eberlein, V, Conzelmann, C, Olari, L R, Rauch, L, Lawrenz, J, Weil, T, Müller, J A, Cardoso, M B, Gilg, A, Larsson, O, Höglund, U, Pålsson, S A, Tvilum, A S, Løvschall, K B, Kristensen, M M, Spetz, A L, Hontonnou, F, Galloux, M, Grunwald, T, Zelikin, A N & Münch, J 2022, ' Macromolecular Viral Entry Inhibitors as Broad-Spectrum First-Line Antivirals with Activity against SARS-CoV-2 ', Advanced Science, vol. 9, no. 20, 2201378 . https://doi.org/10.1002/advs.202201378, Adv. Sci.
- Publication Year :
- 2022
- Publisher :
- HAL CCSD, 2022.
-
Abstract
- International audience; Inhibitors of viral cell entry based on poly(styrene sulfonate) and its core–shell nanoformulations based on gold nanoparticles are investigated against a panel of viruses, including clinical isolates of SARS-CoV-2. Macromolecular inhibitors are shown to exhibit the highly sought-after broad-spectrum antiviral activity, which covers most analyzed enveloped viruses and all of the variants of concern for SARS-CoV-2 tested. The inhibitory activity is quantified in vitro in appropriate cell culture models and for respiratory viral pathogens (respiratory syncytial virus and SARS-CoV-2) in mice. Results of this study comprise a significant step along the translational path of macromolecular inhibitors of virus cell entry, specifically against enveloped respiratory viruses.
- Subjects :
- General Chemical Engineering
RESPIRATORY SYNCYTIAL VIRUS
General Physics and Astronomy
Medicine (miscellaneous)
Metal Nanoparticles
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Antiviral Agents
Mice
Animals
entry inhibitors
[CHIM]Chemical Sciences
General Materials Science
macromolecules
respiratory syncytial virus (RSV)
SARS-CoV-2
General Engineering
RAFT POLYMERIZATION
Virus Internalization
COVID-19 Drug Treatment
in vivo
polyanions
GOLD NANOPARTICLES
CELLS
REPLICATION
broad-spectrum antivirals
Gold
Subjects
Details
- Language :
- English
- ISSN :
- 21983844
- Database :
- OpenAIRE
- Journal :
- Advanced Science, Advanced Science, 2022, 9 (20), pp.2201378. ⟨10.1002/advs.202201378⟩, Groß, R, Dias Loiola, L M, Issmail, L, Uhlig, N, Eberlein, V, Conzelmann, C, Olari, L R, Rauch, L, Lawrenz, J, Weil, T, Müller, J A, Cardoso, M B, Gilg, A, Larsson, O, Höglund, U, Pålsson, S A, Tvilum, A S, Løvschall, K B, Kristensen, M M, Spetz, A L, Hontonnou, F, Galloux, M, Grunwald, T, Zelikin, A N & Münch, J 2022, ' Macromolecular Viral Entry Inhibitors as Broad-Spectrum First-Line Antivirals with Activity against SARS-CoV-2 ', Advanced Science, vol. 9, no. 20, 2201378 . https://doi.org/10.1002/advs.202201378, Adv. Sci.
- Accession number :
- edsair.doi.dedup.....d7dde02e5df70842522aebdc21f15581
- Full Text :
- https://doi.org/10.1002/advs.202201378⟩