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Serum and tissue zinc in epithelial malignancies: a meta-analysis
- Source :
- PLoS ONE, Vol 9, Iss 6, p e99790 (2014), PLOS ONE. 2014, vol. 9, issue 6, p. 1-11., PLoS ONE
- Publication Year :
- 2014
- Publisher :
- Public Library of Science (PLoS), 2014.
-
Abstract
- Background and Objectives: Current studies give us inconsistent results regarding the association of neoplasms and zinc(II) serum and tissues concentrations. The results of to-date studies using meta-analysis are summarized in this paper. Methods: Web of Science (Science citation index expanded), PubMed (Medline), Embase and CENTRAL were searched. Articles were reviewed by two evaluators; quality was assessed by Newcastle-Ottawa scale; meta-analysis was performed including meta-regression and publication bias analysis. Results: Analysis was performed on 114 case control, cohort and cross-sectional studies of 22737 participants. Decreased serum zinc level was found in patients with lung (effect size =21.04), head and neck (effect size =21.43), breast (effect size =20.93), liver (effect size =22.29), stomach (effect size =21.59), and prostate (effect size =21.36) cancers; elevation was not proven in any tumor. More specific zinc patterns are evident at tissue level, showing increase in breast cancer tissue (effect size = 1.80) and decrease in prostatic (effect size =23.90), liver (effect size =28.26), lung (effect size =23.12), and thyroid cancer (effect size =22.84). The rest of the included tumors brought ambiguous results, both in serum and tissue zinc levels across the studies. The association between zinc level and stage or grade of tumor has not been revealed by meta-regression. Conclusion: This study provides evidence on cancer-specific tissue zinc level alteration. Although serum zinc decrease was associated with most tumors mentioned herein, further – prospective - studies are needed. Background and Objectives: Current studies give us inconsistent results regarding the association of neoplasms and zinc(II) serum and tissues concentrations. The results of to-date studies using meta-analysis are summarized in this paper. Methods: Web of Science (Science citation index expanded), PubMed (Medline), Embase and CENTRAL were searched. Articles were reviewed by two evaluators; quality was assessed by Newcastle-Ottawa scale; meta-analysis was performed including meta-regression and publication bias analysis. Results: Analysis was performed on 114 case control, cohort and cross-sectional studies of 22737 participants. Decreased serum zinc level was found in patients with lung (effect size =21.04), head and neck (effect size =21.43), breast (effect size =20.93), liver (effect size =22.29), stomach (effect size =21.59), and prostate (effect size =21.36) cancers; elevation was not proven in any tumor. More specific zinc patterns are evident at tissue level, showing increase in breast cancer tissue (effect size = 1.80) and decrease in prostatic (effect size =23.90), liver (effect size =28.26), lung (effect size =23.12), and thyroid cancer (effect size =22.84). The rest of the included tumors brought ambiguous results, both in serum and tissue zinc levels across the studies. The association between zinc level and stage or grade of tumor has not been revealed by meta-regression. Conclusion: This study provides evidence on cancer-specific tissue zinc level alteration. Although serum zinc decrease was associated with most tumors mentioned herein, further – prospective - studies are needed.
- Subjects :
- Male
Pathology
Colorectal cancer
lcsh:Medicine
Gastroenterology
Biochemistry
Epithelium
Prostate cancer
MetaAnalysis
Prostate
Neoplasms
Breast Tumors
Medicine and Health Sciences
Genitourinary Cancers
lcsh:Science
Thyroid cancer
Multidisciplinary
Prostate Cancer
Prostate Diseases
Head and Neck Tumors
3. Good health
Zinc
medicine.anatomical_structure
Oncology
Research Design
Meta-analysis
Large-cell lung carcinoma
Physical Sciences
Female
Statistics (Mathematics)
Research Article
medicine.medical_specialty
Clinical Research Design
Urology
Epithelial Malignancies
Research and Analysis Methods
Breast cancer
Internal medicine
medicine
Adenocarcinoma of the lung
Cancer Detection and Diagnosis
Humans
Statistical Methods
Benign Prostatic Hyperplasia
Models, Statistical
business.industry
lcsh:R
Biology and Life Sciences
Cancers and Neoplasms
medicine.disease
Genitourinary Tract Tumors
lcsh:Q
business
Biomarkers
Mathematics
Meta-Analysis
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 9
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....d7d39e70ca62b3ed8dc0fda34b6d1a06