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Overexpression of Human Thioredoxin in Transgenic Mice Controls Oxidative Stress and Life Span
- Source :
- Antioxidants & Redox Signaling. 4:693-696
- Publication Year :
- 2002
- Publisher :
- Mary Ann Liebert Inc, 2002.
-
Abstract
- Transgenic (Tg) mice overexpressing human thioredoxin (TRX), a small redox-active protein, were produced to investigate the role of the protein in a variety of stresses. Bone marrow cells from TRX-Tg mice were more resistant to ultraviolet C-induced cytocide compared with those from wild type (WT) C57BL/6 mice. TRX-Tg mice exhibited extended median and maximum life spans compared with WT mice. Telomerase activity in spleen tissues in TRX-Tg mice was higher than that in WT mice. These results suggest that overexpression of TRX results in resistance against oxidative stress and a possible extension of life span without apparent abnormality in mammals.
- Subjects :
- Genetically modified mouse
Telomerase
animal structures
Ultraviolet Rays
Physiology
Transgene
Longevity
Clinical Biochemistry
Human Thioredoxin
Bone Marrow Cells
Mice, Transgenic
Spleen
Biology
medicine.disease_cause
Biochemistry
Mice
Thioredoxins
medicine
Animals
Humans
Molecular Biology
General Environmental Science
Myocardium
Wild type
Brain
Cell Biology
Molecular biology
Mice, Inbred C57BL
Survival Rate
Oxidative Stress
medicine.anatomical_structure
Immunology
General Earth and Planetary Sciences
Bone marrow
Oxidative stress
Subjects
Details
- ISSN :
- 15577716 and 15230864
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Antioxidants & Redox Signaling
- Accession number :
- edsair.doi.dedup.....d7be8278365f66ff4fc10a97a3052dc5