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Trends in Antibiotic Resistance of Nosocomial and Community-Acquired Infections in Italy

Authors :
Paola Cerini
Francesca Rita Meduri
Flaminia Tomassetti
Isabella Polidori
Marta Brugneti
Eleonora Nicolai
Sergio Bernardini
Massimo Pieri
Francesco Broccolo
Source :
Antibiotics; Volume 12; Issue 4; Pages: 651
Publication Year :
2023
Publisher :
Multidisciplinary Digital Publishing Institute, 2023.

Abstract

The World Health Organization has recently identified three categories of pathogens, namely: critical, high, and medium priority, according to the need for new antibiotics. Critical priority pathogens include carbapenem-resistant microorganism (CPO) such as A. baumannii and P. aeruginosa, K. pneumoniae, and Enterobacter spp., whereas vancomycin-resistant E. faecium (VRE), methicillin and vancomycin-resistant S. aureus (MRSA) are in the high priority list. We compared the trend of antimicrobial resistants (AMRs) in clinical isolates, divided by year and bacteria spp., of samples obtained from nosocomial and community patients. Patient records were collected, including age, sex, site of infection, isolated organisms, and drug susceptibility patterns. From 2019 to 2022, a total of 113,635 bacterial isolates were tested, of which 11,901 resulted in antimicrobial resistants. An increase in the prevalence of several antibiotics resistant bacteria was observed. Specifically, the percentage of CPO cases increased from 2.62% to 4.56%, the percentage of MRSA increased from 1.84% to 2.81%, and the percentage of VRE increased from 0.58% to 2.21%. AMRs trend resulted in increases in CPO and MRSA for both community and nosocomial. Our work aims to highlight the necessity of preventive and control measures to be adopted in order to reduce the spread of multidrug-resistant pathogens.

Details

Language :
English
ISSN :
20796382
Database :
OpenAIRE
Journal :
Antibiotics; Volume 12; Issue 4; Pages: 651
Accession number :
edsair.doi.dedup.....d7bb838792961598ddd015d7bc2e368f
Full Text :
https://doi.org/10.3390/antibiotics12040651