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Organic anion transporter 1 and 3 contribute to traditional Chinese medicine-induced nephrotoxicity

Authors :
Jingjing Wang
Luyong Zhang
Zhenzhou Jiang
Debmalya Roy
Xin Huang
Li-Xin Sun
Qingqing Shen
Source :
Chinese journal of natural medicines. 18(3)
Publication Year :
2019

Abstract

With the internationally growing popularity of traditional Chinese medicine (TCM), TCM-induced nephropathy has attracted public attention. Minimizing this toxicity is an important issue for future research. Typical nephrotoxic TCM drugs such as Aristolochic acid, Tripterygium wilfordii Hook. f, Rheum officinale Baill, and cinnabar mainly damage renal proximal tubules or cause interstitial nephritis. Transporters in renal proximal tubule are believed to be critical in the disposition of xenobiotics. In this review, we provide information on the alteration of renal transporters by nephrotoxic TCMs, which may be helpful for understanding the nephrotoxic mechanism of TCMs and reducing adverse effects. Studies have proven that when administering nephrotoxic TCMs, the expression or function of renal transporters is altered, especially organic anion transporter 1 and 3. The alteration of these transporters may enhance the accumulation of toxic drugs or the dysfunction of endogenous toxins and subsequently sensitize the kidney to injury. Transporters-related drug combination and clinical biomarkers supervision to avoid the risk of future toxicity are proposed.

Details

ISSN :
18755364
Volume :
18
Issue :
3
Database :
OpenAIRE
Journal :
Chinese journal of natural medicines
Accession number :
edsair.doi.dedup.....d7b9644ea911849f8f5a7cfbac404ca2