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The role of adiponectin in placentation and preeclampsia
- Source :
- Cell Biochemistry and Function. 38:106-117
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- Preeclampsia is not fully understood; and few biomarkers, therapeutic targets, and therapeutic agents for its management have been identified. Original investigative findings suggest that abnormal placentation triggers preeclampsia and leads to hypertension, proteinuria, endothelial dysfunction, and inflammation, which are characteristics of the disease. Because of the regulatory roles that it plays in several metabolic processes, adiponectin has become a cytokine of interest in metabolic medicine. In this review, we have discussed the role of adiponectin in trophoblast proliferation, trophoblast differentiation, trophoblast invasion of the decidua, and decidual angiogenesis, which are the major phases of placentation. Also, we have highlighted the physiological profile of adiponectin in the course of normal pregnancy. Moreover, we have discussed the involvement of adiponectin in hypertension, endothelial dysfunction, inflammation, and proteinuria. Furthermore, we have summarized the reported relationship between the maternal serum adiponectin level and preeclampsia. The available evidence indicates that adiponectin level physiologically falls as pregnancy advances, regulates placentation, and exhibits protective effects against the symptoms of preeclampsia and that while hyperadiponectinemia is evident in normal-weight preeclamptic women, hypoadiponectinemia is evident in overweight and obese preeclamptic women. Therefore, the clinical use of adiponectin as a biomarker, therapeutic target, or therapeutic agent against the disease looks promising and should be considered.
- Subjects :
- 0301 basic medicine
Angiogenesis
Clinical Biochemistry
Bioinformatics
Biochemistry
Preeclampsia
03 medical and health sciences
0302 clinical medicine
Pre-Eclampsia
Pregnancy
medicine
Humans
Endothelial dysfunction
reproductive and urinary physiology
Adiponectin
business.industry
Decidua
Placentation
Trophoblast
Cell Biology
General Medicine
medicine.disease
female genital diseases and pregnancy complications
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
embryonic structures
Biomarker (medicine)
Female
business
Metabolism, Inborn Errors
Subjects
Details
- ISSN :
- 10990844 and 02636484
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Cell Biochemistry and Function
- Accession number :
- edsair.doi.dedup.....d79a661eb9c423bc1c5646d708c0e37a