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Low Molecular Weight Heparin Nebulization Attenuates Acute Lung Injury
- Source :
- BioMed Research International, Vol 2017 (2017), BioMed Research International
- Publication Year :
- 2017
- Publisher :
- Hindawi, 2017.
-
Abstract
- Background. As acute lung injury (ALI) caused high mortality rate, it is important to explore the protection and treatment of ALI. The aim of the current study is to evaluate the effect of low molecular weight heparin (LMWH) nebulization on attenuating acute lung injury and the associated mechanism. Methods. The arterial blood gas, total protein content in bronchoalveolar lavage fluid, lung wet/dry weight ratio, malondialdehyde (MDA) content, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity, and Akt phosphorylation were evaluated after the ALI rabbits were treated with or without LMWH nebulization. Results. PaO2 was increased and lung wet/dry weight ratio as well as total protein content in BALF was decreased after LMWH nebulization. After the application of LMWH nebulization therapy, the SOD and GSH-Px activity was rebounded and the increase of MDA content was significantly inhibited. The Akt protein phosphorylation level was decreased after LMWH nebulization therapy. Conclusions. LMWH nebulization treatment can relieve the traumatic ALI in rabbits and inhibit oxidative stress possibly by suppressing the Akt phosphorylation.
- Subjects :
- Article Subject
medicine.drug_class
Acute Lung Injury
Low molecular weight heparin
lcsh:Medicine
030204 cardiovascular system & hematology
Pharmacology
Lung injury
medicine.disease_cause
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Malondialdehyde
Administration, Inhalation
medicine
Animals
chemistry.chemical_classification
Glutathione Peroxidase
General Immunology and Microbiology
medicine.diagnostic_test
Inhalation
Superoxide Dismutase
business.industry
Nebulizers and Vaporizers
Glutathione peroxidase
lcsh:R
General Medicine
Heparin
Heparin, Low-Molecular-Weight
respiratory system
respiratory tract diseases
Disease Models, Animal
Bronchoalveolar lavage
030228 respiratory system
chemistry
Anesthesia
Rabbits
business
Oxidative stress
Research Article
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 23146133
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....d7868f770cedb39d2ac9e30dc07c9bf1
- Full Text :
- https://doi.org/10.1155/2017/3169179