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Leptomeningeal Gliomatosis: A Single Institution Study of 31 Patients
- Source :
- Anticancer Research. 39:1035-1041
- Publication Year :
- 2019
- Publisher :
- Anticancer Research USA Inc., 2019.
-
Abstract
- BACKGROUND/AIM Secondary leptomeningeal gliomatosis (LG) is a rare and severe progression pattern of glioma. Our objective was to evaluate the characteristics and outcome of patients with LG. PATIENTS AND METHODS We retrospectively reviewed 31 patients diagnosed with secondary LG. At the time of LG diagnosis, the median age of patients was 45 years. The histological grade was IV in 20 patients and II to III in 11 patients. As a first-line of therapy for LG, 22 patients received an oncological treatment: i) BCNU-temozolomide (TMZ) (n=15), ii) other type of chemotherapy (n=7), and iii) no treatment (supportive care) (n=9). RESULTS Following LG diagnosis, the median progression-free survival (PFS) and overall survival (OS) were 1.8 months [95% confidence interval (CI)=0.9-2.7] and 2.1 months (95%CI=1.3-3), respectively. The univariate analyses showed an improved OS with age of less than 45 years (p
- Subjects :
- Adult
Male
Cancer Research
medicine.medical_specialty
medicine.medical_treatment
Immunoglobulin D
Gastroenterology
Disease-Free Survival
Young Adult
03 medical and health sciences
0302 clinical medicine
Internal medicine
Glioma
Antineoplastic Combined Chemotherapy Protocols
Meningeal Neoplasms
Temozolomide
medicine
Humans
Karnofsky Performance Status
Single institution
Aged
Retrospective Studies
Univariate analysis
Chemotherapy
biology
Brain Neoplasms
business.industry
General Medicine
Middle Aged
Prognosis
medicine.disease
Carmustine
Combined Modality Therapy
Neoplasms, Neuroepithelial
Confidence interval
Treatment Outcome
Oncology
030220 oncology & carcinogenesis
Multivariate Analysis
biology.protein
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 17917530 and 02507005
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Anticancer Research
- Accession number :
- edsair.doi.dedup.....d784568b8c674fa4bf8cc4c2148e7745