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The metabolism of 3,5-di-tert.-butyl-4-hydroxytoluene in the rat and in man
- Source :
- The Biochemical journal. 106(4)
- Publication Year :
- 1968
-
Abstract
- 1. The major metabolites of 3,5-di-tert.-butyl-4-hydroxytoluene (BHT) in the rat are 3,5-di-tert.-butyl-4-hydroxybenzoic acid (BHT-acid), both free (9% of the dose) and as a glucuronide (15%), and S-(3,5-di-tert.-butyl-4-hydroxybenzyl)-N-acetylcysteine. 2. The mercapturic acid does not appear to derive from the usually accepted enzyme mechanism, and may involve a non-enzymic reaction between BHT free radical and cysteine. 3. The ester glucuronide and mercapturic acid found in rat urine are also the major metabolites in rat bile and must be responsible for the enterohepatic circulation. 4. Free BHT-acid is the main component in rat faeces. 5. In man, BHT-acid, free and conjugated, is a minor component in urine, and the mercapturic acid is virtually absent. The bulk of the radioactivity is excreted as the ether-insoluble glucuronide of a metabolite in which the ring methyl group and one tert.-butyl methyl group are oxidized to carboxyl groups, and a methyl group on the other tert.-butyl group is also oxidized, probably to an aldehyde group. 6. These differences in metabolism by the rat and by man are sufficient to account for the difference in excretion by the two species.
- Subjects :
- Male
History
Magnetic Resonance Spectroscopy
Stereochemistry
Chromatography, Paper
Infrared Rays
Ultraviolet Rays
Metabolite
Glucuronates
Aldehyde
Medicinal chemistry
Benzoates
Antioxidants
Education
Excretion
chemistry.chemical_compound
Feces
Animals
Bile
Humans
Cysteine
Mercapturic acid
Enterohepatic circulation
chemistry.chemical_classification
Carbon Isotopes
Spectrum Analysis
Articles
Chromatography, Ion Exchange
Computer Science Applications
Rats
chemistry
Chromatography, Thin Layer
Glucuronide
Methyl group
Toluene
Subjects
Details
- ISSN :
- 02646021
- Volume :
- 106
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- The Biochemical journal
- Accession number :
- edsair.doi.dedup.....d783062a487aed272c6c5570bd0d75aa