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Non-invasive modulation reduces repetitive behavior in a rat model through the sensorimotor cortico-striatal circuit
- Source :
- Translational Psychiatry, Vol 8, Iss 1, Pp 1-13 (2018), Translational Psychiatry, Translational Psychiatry, 8:11
- Publication Year :
- 2018
- Publisher :
- Freie Universität Berlin, 2018.
-
Abstract
- Involuntary movements as seen in repetitive disorders such as Tourette Syndrome (TS) results from cortical hyperexcitability that arise due to striato-thalamo-cortical circuit (STC) imbalance. Transcranial direct current stimulation (tDCS) is a stimulation procedure that changes cortical excitability, yet its relevance in repetitive disorders such as TS remains largely unexplored. Here, we employed the dopamine transporter-overexpressing (DAT-tg) rat model to investigate behavioral and neurobiological effects of frontal tDCS. The outcome of tDCS was pathology dependent, as anodal tDCS decreased repetitive behavior in the DAT-tg rats yet increased it in wild-type (wt) rats. Extensive deep brain stimulation (DBS) application and computational modeling assigned the response in DAT-tg rats to the sensorimotor pathway. Neurobiological assessment revealed cortical activity changes and increase in striatal inhibitory properties in the DAT-tg rats. Our findings show that tDCS reduces repetitive behavior in the DAT-tg rat through modulation of the sensorimotor STC circuit. This sets the stage for further investigating the usage of tDCS in repetitive disorders such as TS.
- Subjects :
- 0301 basic medicine
Male
Deep brain stimulation
medicine.medical_treatment
Rat model
Electroencephalography
Inhibitory postsynaptic potential
Transcranial Direct Current Stimulation
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
Tourette syndrome
Article
Repetitive behavior
lcsh:RC321-571
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Dopamine
medicine
psychiatric disorders
neuroscience
Animals
Rats, Wistar
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Biological Psychiatry
Cerebral Cortex
Dopamine Plasma Membrane Transport Proteins
medicine.diagnostic_test
Transcranial direct-current stimulation
business.industry
medicine.disease
Magnetic Resonance Imaging
Corpus Striatum
Rats
Psychiatry and Mental health
Disease Models, Animal
030104 developmental biology
business
Function and Dysfunction of the Nervous System
Psychiatric disorders
Neuroscience
030217 neurology & neurosurgery
medicine.drug
Tourette Syndrome
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Translational Psychiatry, Vol 8, Iss 1, Pp 1-13 (2018), Translational Psychiatry, Translational Psychiatry, 8:11
- Accession number :
- edsair.doi.dedup.....d76acaa4b815e274e5fdbe443a5346fd