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Neuropathologic features associated with basal forebrain atrophy in Alzheimer disease
- Source :
- Digital.CSIC. Repositorio Institucional del CSIC, instname, Neurology, article-version (Version of Record) 3, Neurology 95(10), e1301-e1311 (2020). doi:10.1212/WNL.0000000000010192
- Publication Year :
- 2020
- Publisher :
- American Academy of Neurology, 2020.
-
Abstract
- Alzheimer's Disease Neuroimaging Initiative.<br />[Objective] To study the neuropathologic correlates of cholinergic basal forebrain (BF) atrophy as determined using antemortem MRI in the Alzheimer disease (AD) spectrum.<br />[Methods] We determined associations between BF volume from antemortem MRI brain scans and postmortem assessment of neuropathologic features, including neuritic plaques, neurofibrillary tangles (NFTs), Lewy body (LB) pathology, and TDP-43, in 64 cases of the Alzheimer's Disease Neuroimaging Initiative cohort. For comparison, we assessed neuropathologic features associated with hippocampal and parahippocampal gyrus atrophy. In addition to region of interest–based analysis, we determined the association of neuropathologic features with whole brain gray matter volume using regionally unbiased voxel-based volumetry.<br />[Results] BF atrophy was associated with Thal amyloid phases (95% confidence interval [CI] −0.49 to −0.01, p = 0.049) and presence of LB pathology (95% CI −0.54 to −0.06, p = 0.015), as well as with the degree of LB pathology within the nucleus basalis Meynert (95% CI −0.54 to −0.07, p = 0.025). These effects were no longer significant after false discovery rate (FDR) correction. Hippocampal atrophy was significantly associated with the presence of TDP-43 pathology (95% CI −0.61 to −0.17, p = 0.003; surviving FDR correction), in addition to dentate gyrus NFT load (95% CI −0.49 to −0.01, p = 0.044; uncorrected). Voxel-based analysis confirmed spatially restricted effects of Thal phases and presence of LB pathology on BF volume.<br />[Conclusions] These findings indicate that neuropathologic correlates of regional atrophy differ substantially between different brain regions that are typically involved in AD-related neurodegeneration, including different susceptibilities to common comorbid pathologies.<br />M.J.G. is supported by the “Miguel Servet” program [CP19/00031] of the Spanish Instituto de Salud Carlos III (ISCIII-FEDER).
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Multivariate analysis
diagnostic imaging [Basal Forebrain]
Basal Forebrain
pathology [Basal Forebrain]
Logistic regression
Article
03 medical and health sciences
pathology [Alzheimer Disease]
0302 clinical medicine
Atrophy
Alzheimer Disease
Internal medicine
Ischaemic stroke
Medicine
Humans
ddc:610
Stroke
Cost implications
Aged
Aged, 80 and over
pathology [Atrophy]
business.industry
medicine.disease
Magnetic Resonance Imaging
030104 developmental biology
Charlson comorbidity index
Female
Neurology (clinical)
Alzheimer's disease
business
diagnostic imaging [Alzheimer Disease]
030217 neurology & neurosurgery
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Digital.CSIC. Repositorio Institucional del CSIC, instname, Neurology, article-version (Version of Record) 3, Neurology 95(10), e1301-e1311 (2020). doi:10.1212/WNL.0000000000010192
- Accession number :
- edsair.doi.dedup.....d74504bcbfd2ed11bb998527451000a0