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Limited allelic diversity of stimulatory two-domain killer cell immunoglobulin-like receptors
- Source :
- Human Immunology. 69:174-178
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- Genomic sequencing was used to characterize most of the coding regions of the five two-domain stimulatory killer cell immunoglobulin-like receptor (KIR) loci from 80 unrelated, primarily Caucasian, individuals. Specific loci were present in from 26% (KIR2DS3) to 98% (KIR2DS4) of individuals. The number of known alleles present varied from one (KIR2DS1, KIR2DS5) to five (KIR2DS4). The frequencies of loci and alleles were similar to observations made in populations of European and Asian ethnicities. New alleles were found at 2DS1 (*00202, *00302, *005, *006, *007) and 2DS4 (*008) loci.
- Subjects :
- Genetics
B-Lymphocytes
Genomic Library
Immunology
Killer-cell immunoglobulin-like receptor
Genetic Variation
General Medicine
Immunogenetics
Immune receptor
Biology
Polymerase Chain Reaction
Receptors, KIR
Humans
Immunology and Allergy
Coding region
Genomic library
Allele
Receptor
Alleles
Bone Marrow Transplantation
Cell Line, Transformed
KIR2DS4
Subjects
Details
- ISSN :
- 01988859
- Volume :
- 69
- Database :
- OpenAIRE
- Journal :
- Human Immunology
- Accession number :
- edsair.doi.dedup.....d704fe91f2458f81e0572f037b4d83c2