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The Association of Gene Variants in the Vitamin D Metabolic Pathway and Its Interaction with Vitamin D on Gestational Diabetes Mellitus: A Prospective Cohort Study
- Source :
- Nutrients, Nutrients, Vol 13, Iss 4220, p 4220 (2021), Nutrients; Volume 13; Issue 12; Pages: 4220
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- The present prospective study included 2156 women and investigated the effect of gene variants in the vitamin D (VitD) metabolic and glucose pathways and their interaction with VitD levels during pregnancy on gestational diabetes mellitus (GDM). Plasma 25(OH)D concentrations were measured at the first and second trimesters. GDM subtype 1 was defined as those with isolated elevated fasting plasma glucose; GDM subtype 2 were those with isolated elevated postprandial glucose at 1 h and/or 2 h; and GDM subtype 3 were those with both elevated fasting plasma glucose and postprandial glucose. Six Gc isoforms were categorized based on two GC gene variants rs4588 and rs7041, including 1s/1s, 1s/2, 1s/1f, 2/2, 1f/2 and 1f/1f. VDR-rs10783219 and MTNR1B-rs10830962 were associated with increased risks of GDM and GDM subtype 2; interactions between each other as well as with CDKAL1-rs7754840 were observed (Pinteraction < 0.05). Compared with the 1f/1f isoform, the risk of GDM subtype 2 among women with 1f/2, 2/2, 1s/1f, 1s/2 and 1s/1s isoforms and with prepregnancy body mass index ≥24 kg/m2 increased by 5.11, 10.01, 10, 14.23, 19.45 times, respectively. Gene variants in VitD pathway interacts with VitD deficiency at the first trimester on the risk of GDM and GDM subtype 2.
- Subjects :
- Gene isoform
Adult
Blood Glucose
medicine.medical_specialty
endocrine system diseases
gene polymorphism
vitamin D
Article
Body Mass Index
Pregnancy
Risk Factors
Internal medicine
medicine
Vitamin D and neurology
Humans
TX341-641
gestational diabetes mellitus
subtypes
Prospective Studies
Prospective cohort study
Nutrition and Dietetics
business.industry
Nutrition. Foods and food supply
nutritional and metabolic diseases
Genetic Variation
Fasting
medicine.disease
Vitamin D Deficiency
female genital diseases and pregnancy complications
Gestational diabetes
Diabetes, Gestational
Postprandial
Endocrinology
Female
Gene polymorphism
Pregnancy Trimesters
business
Body mass index
Metabolic Networks and Pathways
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Volume :
- 13
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....d6faaab759c99771097a1e15e5b67b05