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Differential auditory brain response abnormalities in two intellectual disability conditions: SYNGAP1 mutations and Down syndrome
- Source :
- Clinical Neurophysiology. 132:1802-1812
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Objective Altered sensory processing is common in intellectual disability (ID). Here, we study electroencephalographic responses to auditory stimulation in human subjects presenting a rare condition (mutations in SYNGAP1) which causes ID, epilepsy and autism. Methods Auditory evoked potentials, time-frequency and inter-trial coherence analyses were used to compare subjects with SYNGAP1 mutations with Down syndrome (DS) and neurotypical (NT) participants (N = 61 ranging from three to 19 years of age). Results Altered synchronization in the brain responses to sound were found in both ID groups. The SYNGAP1 mutations group showed less phase-locking in early time windows and lower frequency bands compared to NT, and in later time windows compared to NT and DS. Time-frequency analysis showed more power in beta-gamma in the SYNGAP1 group compared to NT participants. Conclusions This study indicated reduced synchronization as well as more high frequencies power in SYNGAP1 mutations, while maintained synchronization was found in the DS group. These results might reflect dysfunctional sensory information processing caused by excitation/inhibition imbalance, or an imperfect compensatory mechanism in SYNGAP1 mutations individuals. Significance Our study is the first to reveal brain response abnormalities in auditory sensory processing in SYNGAP1 mutations individuals, that are distinct from DS, another ID condition.
- Subjects :
- Male
medicine.medical_specialty
Down syndrome
Adolescent
Sensory processing
medicine.medical_treatment
Audiology
SYNGAP1
050105 experimental psychology
Cohort Studies
Young Adult
03 medical and health sciences
Epilepsy
0302 clinical medicine
Time windows
Intellectual Disability
Physiology (medical)
Intellectual disability
medicine
Humans
0501 psychology and cognitive sciences
Child
business.industry
05 social sciences
Electroencephalography
medicine.disease
Sensory Systems
Acoustic Stimulation
Neurology
ras GTPase-Activating Proteins
Child, Preschool
Mutation
Evoked Potentials, Auditory
Autism
Female
Neurology (clinical)
Down Syndrome
business
030217 neurology & neurosurgery
Neurotypical
Subjects
Details
- ISSN :
- 13882457
- Volume :
- 132
- Database :
- OpenAIRE
- Journal :
- Clinical Neurophysiology
- Accession number :
- edsair.doi.dedup.....d6f99b2eb305c9e8ace9f146d3fbc5f9