Back to Search
Start Over
Syringocystadenocarcinoma papilliferum with transition to areas of squamous differentiation: a case report and review of the literature
- Source :
- The American Journal of dermatopathology. 34(4)
- Publication Year :
- 2012
-
Abstract
- Syringocystadenocarcinoma papilliferum (SCACP) is an exceedingly rare cutaneous adnexal neoplasm, which is typically located in the head and neck, and perianal area. Very few cases have been reported in the literature. Here, we report a case of SCACP with evident transition to squamous differentiation. A 75-year-old white woman presented with 1-year history of a solitary tender nodule in the left upper arm. Physical examination revealed a single, 1.5 × 1.1-cm, erythematous ulcerated nodule within a background of red patch. Biopsy showed an adnexal carcinoma connected to the epidermis and composed of cystic papillary projections admixed with solid basaloid areas with marked cytologic atypia. The basaloid tumor cells appeared to blend with the squamous component that demonstrated ductal formation, which was highlighted by carcinoembryonic antigen. Tumor cells were reactive for both cytokeratins 5/6 and 7. This case represents SCACP arising from syringocystadenoma papilliferum in the upper arm, with distinct transition to areas of squamous differentiation.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Squamous Differentiation
Biopsy
Dermatology
Pathology and Forensic Medicine
Carcinoembryonic antigen
medicine
Biomarkers, Tumor
Humans
Neoplasm Invasiveness
Cystadenocarcinoma
Aged
Aged, 80 and over
biology
medicine.diagnostic_test
business.industry
Nodule (medicine)
Cell Differentiation
General Medicine
Middle Aged
medicine.disease
Immunohistochemistry
Treatment Outcome
biology.protein
Cystadenocarcinoma, Papillary
Female
Neoplasms, Adnexal and Skin Appendage
medicine.symptom
business
Syringocystadenoma papilliferum
Adnexal Carcinoma
Subjects
Details
- ISSN :
- 15330311
- Volume :
- 34
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- The American Journal of dermatopathology
- Accession number :
- edsair.doi.dedup.....d6f89d180a037a72199f5d6802669961