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Primary leptomeningeal T-cell lymphoblastic lymphoma: a rare cause of chronic meningitis
- Source :
- BMJ Case Rep
- Publication Year :
- 2020
- Publisher :
- BMJ, 2020.
-
Abstract
- Primary leptomeningeal lymphomatosis is a rare disease with only a few hundred cases reported. We present a patient with a relatively short history of 25 days of headache followed by diplopia who was found to have primary leptomeningeal T-cell lymphoma without evidence of systemic lymphoma. The patient responded well to chemotherapy along with intrathecal medication and cranial irradiation and returned to a completely normal state of health. Not all chronic meningitis is due to infection or self-limiting inflammatory causes. It is important to consider lymphoma as a differential even in the absence of constitutional features such as loss of weight, appetite, night sweats, lymphadenopathy or hepatosplenomegaly. T-cell lymphoma with only Central Nervous system (CNS) involvement is a rare cause of chronic meningitis, which is eminently amenable to treatment and is fatal if missed.
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
Neurology
Fever
medicine.medical_treatment
Hepatosplenomegaly
030105 genetics & heredity
Lymphoma, T-Cell
Dexamethasone
Diagnosis, Differential
03 medical and health sciences
Meninges
0302 clinical medicine
Rare Disease
Antineoplastic Combined Chemotherapy Protocols
Meningeal Neoplasms
medicine
Humans
Meningitis
Cyclophosphamide
Injections, Spinal
Diplopia
Chemotherapy
business.industry
Lymphoblastic lymphoma
Headache
Neurooncology
General Medicine
medicine.disease
Magnetic Resonance Imaging
Dermatology
Lymphoma
Methotrexate
Treatment Outcome
Doxorubicin
Vincristine
Chronic Disease
Cranial Irradiation
medicine.symptom
business
030217 neurology & neurosurgery
Rare disease
Subjects
Details
- ISSN :
- 1757790X
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- BMJ Case Reports
- Accession number :
- edsair.doi.dedup.....d6ec36e5177a33c4760ae7587e3f350a
- Full Text :
- https://doi.org/10.1136/bcr-2020-236491