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Effect of acute exercise on RBC deformability and RBC nitric oxide synthase signalling pathway in young sickle cell anaemia patients
- Source :
- Scientific Reports, Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-48364-1⟩, Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Sickle cell anaemia (SCA) is characterized by reduced red blood cell (RBC) deformability and nitric oxide (NO) bioavailability. The aim of the study was to investigate whether exercise might affect these parameters in SCA. SCA patients and healthy controls (AA) performed an acute submaximal exercise test until subjects reached the first ventilatory threshold (VT 1). Blood was sampled at rest and at VT 1. At rest, free haemoglobin level was higher and RBC count, haemoglobin and haematocrit were lower in SCA compared to AA. RBC deformability was lower in SCA. Exercise had no effect on the tested parameters. RBC NO level was higher in SCA compared to AA at rest and significantly decreased after exercise in SCA. This might be related to a reduction in RBC-NO synthase (RBC-NOS) activation which was only observed in SCA after exercise. Free radical levels were higher in SCA at rest but concentration was not affected by exercise. Marker for lipid peroxidation and antioxidative capacity were similar in SCA and AA and not affected by exercise. In conclusion, a single acute submaximal bout of exercise has no deleterious effects on RBC deformability or oxidative stress markers in SCA, and seems to modulate RBC-NOS signalling pathway.
- Subjects :
- Male
0301 basic medicine
Erythrocytes
Lipid peroxidation
[SCCO]Cognitive science
chemistry.chemical_compound
0302 clinical medicine
Erythrocyte deformability
ComputingMilieux_MISCELLANEOUS
reproductive and urinary physiology
Multidisciplinary
biology
hemic and immune systems
Nitric oxide synthase
medicine.anatomical_structure
Medicine
Female
Signal Transduction
circulatory and respiratory physiology
medicine.medical_specialty
Adolescent
Anemia
Science
Anemia, Sickle Cell
Article
Nitric oxide
03 medical and health sciences
Erythrocyte Deformability
Internal medicine
medicine
Humans
Exercise physiology
Exercise
business.industry
Sickle cell disease
Diagnostic markers
medicine.disease
Oxidative Stress
Red blood cell
030104 developmental biology
Endocrinology
chemistry
Case-Control Studies
biology.protein
Nitric Oxide Synthase
Ventilatory threshold
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....d6ea82b156f30955ad2567efccf0bca9