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Instrumental validation of free water, peak-width of skeletonized mean diffusivity, and white matter hyperintensities: MarkVCID neuroimaging kits

Authors :
Pauline, Maillard
Hanzhang, Lu
Konstantinos, Arfanakis
Brian T, Gold
Christopher E, Bauer
Valentinos, Zachariou
Lara, Stables
Danny J J, Wang
Kay, Jann
Sudha, Seshadri
Marco, Duering
Laura J, Hillmer
Gary A, Rosenberg
Haykel, Snoussi
Farshid, Sepehrband
Mohamad, Habes
Baljeet, Singh
Joel H, Kramer
Roderick A, Corriveau
Herpreet, Singh
Kristin, Schwab
Karl G, Helmer
Steven M, Greenberg
Arvind, Caprihan
Charles, DeCarli
Claudia L, Satizabal
Source :
Alzheimer'sdementia (Amsterdam, Netherlands). 14(1)
Publication Year :
2021

Abstract

To describe the protocol and findings of the instrumental validation of three imaging-based biomarker kits selected by the MarkVCID consortium: free water (FW) and peak width of skeletonized mean diffusivity (PSMD), both derived from diffusion tensor imaging (DTI), and white matter hyperintensity (WMH) volume derived from fluid attenuation inversion recovery and T1-weighted imaging.The instrumental validation of imaging-based biomarker kits included inter-rater reliability among participating sites, test-retest repeatability, and inter-scanner reproducibility across three types of magnetic resonance imaging (MRI) scanners using intra-class correlation coefficients (ICC).The three biomarkers demonstrated excellent inter-rater reliability (ICC 0.94,The three biomarker kits demonstrated very high inter-rater reliability, test-retest repeatability, and inter-scanner reproducibility, offering robust biomarkers suitable for future multi-site observational studies and clinical trials in the context of vascular cognitive impairment and dementia (VCID).

Details

ISSN :
23528729
Volume :
14
Issue :
1
Database :
OpenAIRE
Journal :
Alzheimer'sdementia (Amsterdam, Netherlands)
Accession number :
edsair.doi.dedup.....d6e5fbfdce53460cac3c0b6dc3222085