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SEX DIFFERENCES IN THORACIC AORTIC ANEURYSM GROWTH: ROLE OF AORTIC STIFFNESS
- Source :
- Journal of the American College of Cardiology. 69:2041
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Women with thoracic aortic aneurysms (TAAs) have higher risk of acute aortic syndromes and death than men. We have shown that TAA growth is accelerated in women, helping explain the sex differences in TAA outcomes. Since aortic stiffness reflects the health of the aorta, we sought to determine the sex-specific role of aortic stiffness on TAA growth. One hundred thirty unoperated people with TAA were recruited. Maximal aneurysm size at the oldest and latest imaging studies was measured to calculate TAA growth rate. Aortic stiffness was assessed by carotid-femoral pulse wave velocity (cfPWV) using applanation tonometry. Multivariable linear regression adjusted for confounders assessed the association of cfPWV with TAA growth. Seventy-three percent of subjects were men. Mean±SD age, baseline aneurysm size, follow-up time, and cfPWV were 62.5±11.5 years, 45.3±4.0 mm, 3.3±3.0 years and 9.6±3.5 m/s, and not different based on sex. TAA growth rate was 0.96±1.00 mm/y in women and 0.45±0.58 mm/y in men ( P =0.006). In the whole group, cfPWV was independently associated with TAA growth (β±SE: 0.06±0.02, P =0.02). However, in sex-specific analyses cfPWV was independently associated with faster aneurysm growth in women (β±SE: 0.21±0.09, P =0.03), but not in men (β±SE: −0.002±0.02, P =0.94), with a significant sex×cfPWV interaction ( P
- Subjects :
- medicine.medical_specialty
030204 cardiovascular system & hematology
complex mixtures
Thoracic aortic aneurysm
03 medical and health sciences
0302 clinical medicine
Aneurysm
medicine.artery
Internal medicine
parasitic diseases
Internal Medicine
Medicine
In patient
030212 general & internal medicine
Pulse wave velocity
Aorta
business.industry
Confounding
medicine.disease
digestive system diseases
cardiovascular system
Cardiology
Aortic stiffness
Cardiology and Cardiovascular Medicine
business
Sex characteristics
Subjects
Details
- ISSN :
- 07351097
- Volume :
- 69
- Database :
- OpenAIRE
- Journal :
- Journal of the American College of Cardiology
- Accession number :
- edsair.doi.dedup.....d6e5a267384ac9cf1b0dd30f1800e5d4
- Full Text :
- https://doi.org/10.1016/s0735-1097(17)35430-x