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C-reactive protein as a potential biomarker in psychiatric practice: Are we there yet?
- Source :
- The World Journal of Biological Psychiatry. 23:243-256
- Publication Year :
- 2021
- Publisher :
- Informa UK Limited, 2021.
-
Abstract
- Objectives: Serum or plasma levels of C-reactive protein (CRP) and highsensitivity CRP (hsCRP) are widely used clinical markers of inflammation in other branches of medicine, whereas its clinical use in psychiatry has been limited to research studies. We aimed to assess the possibility of using CRP/hsCRP in psychiatric practice. This is a review and evaluation of various lines of evidence supporting the concept of CRP as a biomarker for psychiatric disorders in certain conditions. Methods: We searched the literature for studies which assessed CRP/hsCRP levels in various psychiatric disorders. Results: The accumulating evidence from large studies and meta-analyses allows us to understand the role of CRP in major psychiatric disorders and increase our understanding of specific symptoms and subtypes of disorders. CRP may be considered a “psychiatric biomarker” which can alert clinicians about neuroinflammation, adverse effects of medications, cardiometabolic status, comorbidities, and may also predict clinical outcomes and guide optimal treatment selection. Conclusion: Although the underlying pathophysiological role of CRP and hsCRP is still elusive and the association between CRP and psychiatric disorders is inconsistent, CRP holds promise to become a psychiatric biomarker. WOS:000684418100001 34323645 Q2
- Subjects :
- Psychiatry
Inflammation
biology
business.industry
C-reactive protein
Comorbidity
Plasma levels
hsCRP
Psychiatry and Mental health
C-Reactive Protein
Neuroinflammation
Potential biomarkers
Immunology
biology.protein
Humans
Medicine
cardiovascular diseases
medicine.symptom
CRP
business
Biomarkers
Biological Psychiatry
Subjects
Details
- ISSN :
- 18141412 and 15622975
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- The World Journal of Biological Psychiatry
- Accession number :
- edsair.doi.dedup.....d6dbffc0acec8e0372862b5beae6ead9