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The Insight into Insulin-Like Growth Factors and Insulin-Like Growth-Factor-Binding Proteins and Metabolic Profile in Pediatric Obesity
- Source :
- Nutrients; Volume 13; Issue 7; Pages: 2432, Nutrients, Vol 13, Iss 2432, p 2432 (2021), Nutrients
- Publication Year :
- 2021
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2021.
-
Abstract
- Insulin-like growth factors (IGFs) and insulin-like growth-factor-binding proteins (IGFBPs) regulate cell proliferation and differentiation and may be of importance in obesity development. The aim of the study was to analyze the expression of chosen IGF-axis genes and the concentration of their protein products in 28 obese children (OB) and 34 healthy control (HC), and their correlation with essential parameters associated with childhood obesity. The gene expression of IGFBP7 was higher, and the expression of IGF2 and IGFBP1 genes was lower in the OB. The expression of IGFBP6 tended to be lower in OB. IGFBP4 concentration was significantly higher, and IGFBP3 tended to be higher in the OB compared to the HC, while IGFBP1, IGFBP2, and IGFBP6 were significantly lower, and IGFBP7 tended to be lower in OB. We found numerous correlations between IGFs and IGFBP concentration and obesity metabolic parameters. IGFBP6 correlated positively with apelin, cholecystokinin, glucagone-like peptide-1, and leptin receptor. These peptides were also significantly lower in obese children in our study. The biological role of decreased levels of IGFBP6 in obese children needs further investigation.
- Subjects :
- Male
0301 basic medicine
Pediatric Obesity
medicine.medical_specialty
obesity
IGF
IGFBP
children
microarray
Adolescent
IGFBP7
medicine.medical_treatment
IGFBP3
Enzyme-Linked Immunosorbent Assay
030209 endocrinology & metabolism
Article
Insulin-like growth factor-binding protein
03 medical and health sciences
0302 clinical medicine
Adipokines
Insulin-Like Growth Factor II
Internal medicine
medicine
Humans
IGFBP1
TX341-641
Insulin-Like Growth Factor I
Child
Oligonucleotide Array Sequence Analysis
Nutrition and Dietetics
Leptin receptor
biology
Nutrition. Foods and food supply
Gene Expression Profiling
Insulin
medicine.disease
Obesity
Apelin
Insulin-Like Growth Factor Binding Proteins
030104 developmental biology
Endocrinology
Gene Expression Regulation
Case-Control Studies
Child, Preschool
biology.protein
Female
Biomarkers
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Database :
- OpenAIRE
- Journal :
- Nutrients; Volume 13; Issue 7; Pages: 2432
- Accession number :
- edsair.doi.dedup.....d6da7a7a64116aa3c2e79aa07e9a0650
- Full Text :
- https://doi.org/10.3390/nu13072432