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The Insight into Insulin-Like Growth Factors and Insulin-Like Growth-Factor-Binding Proteins and Metabolic Profile in Pediatric Obesity

Authors :
Emil Krzysztofik
Albert Wróbel
Szymon Skoczeń
Małgorzata Wójcik
Wojciech Strojny
Wojciech Czogała
Klaudia Miklusiak
Karol Miklusiak
Przemysław Tomasik
Mirosław Bik Multanowski
Source :
Nutrients; Volume 13; Issue 7; Pages: 2432, Nutrients, Vol 13, Iss 2432, p 2432 (2021), Nutrients
Publication Year :
2021
Publisher :
Multidisciplinary Digital Publishing Institute, 2021.

Abstract

Insulin-like growth factors (IGFs) and insulin-like growth-factor-binding proteins (IGFBPs) regulate cell proliferation and differentiation and may be of importance in obesity development. The aim of the study was to analyze the expression of chosen IGF-axis genes and the concentration of their protein products in 28 obese children (OB) and 34 healthy control (HC), and their correlation with essential parameters associated with childhood obesity. The gene expression of IGFBP7 was higher, and the expression of IGF2 and IGFBP1 genes was lower in the OB. The expression of IGFBP6 tended to be lower in OB. IGFBP4 concentration was significantly higher, and IGFBP3 tended to be higher in the OB compared to the HC, while IGFBP1, IGFBP2, and IGFBP6 were significantly lower, and IGFBP7 tended to be lower in OB. We found numerous correlations between IGFs and IGFBP concentration and obesity metabolic parameters. IGFBP6 correlated positively with apelin, cholecystokinin, glucagone-like peptide-1, and leptin receptor. These peptides were also significantly lower in obese children in our study. The biological role of decreased levels of IGFBP6 in obese children needs further investigation.

Details

Language :
English
ISSN :
20726643
Database :
OpenAIRE
Journal :
Nutrients; Volume 13; Issue 7; Pages: 2432
Accession number :
edsair.doi.dedup.....d6da7a7a64116aa3c2e79aa07e9a0650
Full Text :
https://doi.org/10.3390/nu13072432