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Mechanism of salidroside relieving the acute hypoxia-induced myocardial injury through the PI3K/Akt pathway
- Source :
- Saudi Journal of Biological Sciences, Saudi Journal of Biological Sciences, Vol 27, Iss 6, Pp 1533-1537 (2020)
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Objective: The objective was to investigate the anti-inflammatory effects of salidroside through the PI3K/Akt signaling pathway and its protective effects on acute hypoxia-induced myocardial injury in rats. Methods: A total of 24 healthy Sprague-Dawley male rats were selected as the experimental subjects. All rats were divided into 4 groups by using the random number table method, with 6 rats in each group. The groups included the normal control group, the salidroside group, the hypobaric hypoxia group, and the hypobaric hypoxia + salidroside group. Rats in the salidroside group were fed in the original animal laboratory and were intragastrically administered with salidroside every morning at a dosage of 35 mg/kg. Rats in the normal control group were intragastrically administered with an equal dosage of saline. Rats in the hypobaric hypoxia + salidroside group were intragastrically administered with salidroside every morning at a dosage of 35 mg/kg, who were fed in the hypoxic experiment module for animals. The altitude was increased to 4000 m, and the rats were kept in the module for 24 h. Rats in the hypobaric hypoxia group were intragastrically administered with an equal dosage of saline in the same environment, and the altitude was increased to 4000 m after administration. Parameters of blood gas analysis, histopathological changes in cardiac tissues, cardiac indexes, and inflammatory factors IL-6 and TNF-α levels of rats in groups were compared. Results: 1. The cardiac indexes of rats in groups were compared. The differences between the hypobaric hypoxia group and the hypobaric hypoxia + salidroside group were statistically significant (P
- Subjects :
- 0106 biological sciences
0301 basic medicine
medicine.medical_specialty
Necrosis
medicine.medical_treatment
Hypobaric hypoxia
01 natural sciences
Article
03 medical and health sciences
chemistry.chemical_compound
Acute hypoxia
Edema
Internal medicine
medicine
lcsh:QH301-705.5
Saline
PI3K/AKT/mTOR pathway
Akt/PKB signaling pathway
business.industry
Salidroside
030104 developmental biology
Endocrinology
lcsh:Biology (General)
chemistry
PI3K/Akt pathway
Myocardial injury
medicine.symptom
General Agricultural and Biological Sciences
business
Pyknosis
010606 plant biology & botany
Subjects
Details
- ISSN :
- 1319562X
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Saudi Journal of Biological Sciences
- Accession number :
- edsair.doi.dedup.....d6da25119aadf03d459d4245d8cfd1fc