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Helicobacter pylori infection increases risk of incident metabolic syndrome and diabetes: A cohort study
- Source :
- PLoS ONE, PLoS ONE, Vol 14, Iss 2, p e0208913 (2019)
- Publication Year :
- 2019
- Publisher :
- Public Library of Science, 2019.
-
Abstract
- Emerging studies have shed light on the association between Helicobacter pylori (HP) infection and cardiometabolic risk. However, there is no evidence to support a causal link for the relationship in the general population. Our aim was to determine whether HP infection is associated with the risks of incident type II diabetes mellitus (DM) in a population-based cohort consisting of adults from the general population. A total of 69235 adults enrolled in the study obtained health examinations at the Tri-Service General Hospital in Taiwan from 2010 to 2016. HP infection detection was performed by rapid urease tests (RUTs), and endoscopic examinations were used to diagnose gastroesophageal reflux disease (GERD), gastric ulcers (GUs) and duodenal ulcers (DUs). Cross-sectional and longitudinal analyses were performed to examine the association between HP infection and cardiometabolic diseases using logistic regression and Cox regression in a large population-based study. HP infection was significantly associated with the presence of metabolic syndrome (MetS) (OR = 1.26, 95%CI: 1.00-1.57) and DM (OR = 1.59, 95%CI: 1.17-2.17) only in male subjects, and abnormal endoscopic findings were also correlated with cardiometabolic diseases. Our findings demonstrated that participants with HP infection had an elevated risk of developing incident DM (HR = 1.54, 95%CI: 1.11-2.13). In addition, endoscopic findings of a DU (HR = 1.63, 95%CI: 1.02-2.63), rather than GERD or a GU, were also predictive of incident DM. In this cohort, HP infection was a statistically significant predictor of incident DM among male population.
- Subjects :
- Bacterial Diseases
Male
Cross-sectional study
Peptide Hormones
Pathology and Laboratory Medicine
Biochemistry
Gastroesophageal Reflux Disease
Cohort Studies
0302 clinical medicine
Endocrinology
Medicine and Health Sciences
Gastrointestinal Infections
Longitudinal Studies
Immune Response
Metabolic Syndrome
education.field_of_study
Multidisciplinary
biology
Middle Aged
Enzymes
Infectious Diseases
030220 oncology & carcinogenesis
Cohort
Ureases
Gastroesophageal Reflux
Medicine
030211 gastroenterology & hepatology
Female
Cohort study
Research Article
medicine.medical_specialty
Endocrine Disorders
Science
Population
Immunology
Taiwan
Surgical and Invasive Medical Procedures
Gastroenterology and Hepatology
Helicobacter Infections
03 medical and health sciences
Signs and Symptoms
Diagnostic Medicine
Internal medicine
Diabetes mellitus
medicine
Diabetes Mellitus
Humans
Stomach Ulcer
education
Thyroid-Stimulating Hormone
Inflammation
Helicobacter pylori
business.industry
Biology and Life Sciences
Proteins
Endoscopy
medicine.disease
biology.organism_classification
Hormones
Helicobacter Pylori Infection
Cross-Sectional Studies
Diabetes Mellitus, Type 2
Metabolic Disorders
Duodenal Ulcer
GERD
Enzymology
Metabolic syndrome
business
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 14
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....d6d61ec8b9a0f8d838ede99c128d21a3