Back to Search
Start Over
Fragile X Premutation Is a Significant Risk Factor for Premature Ovarian Failure: The International Collaborative POF in Fragile X Study—Preliminary Data
- Publication Year :
- 1999
-
Abstract
- The preliminary results of an international collaborative study examining premature menopause in fragile X carriers are presented. A total of 760 women from fragile X families was surveyed about their fragile X carrier status and their menstrual and reproductive histories. Among the subjects, 395 carried a premutation, 128 carried a full mutation, and 237 were noncarriers. Sixty-three (16%) of the premutation carriers had experienced menopause prior to the age of 40 compared with none of the full mutation carriers and one (0.4%) of the controls. Based on these preliminary data, there is a significant association between fragile X premutation carrier status and premature menopause.
- Subjects :
- Adult
medicine.medical_specialty
Heterozygote
Adolescent
media_common.quotation_subject
International Cooperation
Primary Ovarian Insufficiency
Article
Risk Factors
Internal medicine
medicine
Humans
Risk factor
Genetics (clinical)
Menstrual cycle
Premature Menopause
Menstrual Cycle
media_common
Fragile X Tremor/Ataxia Syndrome
business.industry
Obstetrics
Middle Aged
medicine.disease
Premature ovarian failure
Menopause
Fragile X syndrome
Endocrinology
Fragile X Syndrome
Female
business
Fragile X-associated tremor/ataxia syndrome
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....d6ce44f3987b42e8b1cadf1ef8638460