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The making of the mitotic chromosome: modern insights into classical questions
- Source :
- Molecular cell. 11(3)
- Publication Year :
- 2003
-
Abstract
- The condensation of mitotic chromosomes is essential for the faithful segregation of sister chromatids in anaphase. An emerging view is that chromosome assembly is an active and dynamic process of chromatin reorganization in which two ATP hydrolyzing enzymes, topoisomerase II and the condensin complex, play central roles. In this review, we discuss recent work that sheds new light on the molecular and structural dynamics of mitotic chromosomes.
- Subjects :
- Condensin
Mitosis
Apoptosis
Chromatids
Chromosomes
Histones
Condensin complex
Prophase
Adenosine Triphosphate
Sister chromatids
Animals
Humans
Phosphorylation
Molecular Biology
Anaphase
Genetics
Adenosine Triphosphatases
biology
Hydrolysis
Cell Biology
DNA
Condensin I complex
Chromatin
Cell biology
DNA-Binding Proteins
DNA Topoisomerases, Type II
Multiprotein Complexes
biology.protein
Nucleic Acid Conformation
Subjects
Details
- ISSN :
- 10972765
- Volume :
- 11
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Molecular cell
- Accession number :
- edsair.doi.dedup.....d6cd69bfd8ed1375896ad6c7dbd87a30