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Predicting Progression to Parkinson's Disease Dementia Using Multivariate Normative Comparisons
- Source :
- Journal of the International Neuropsychological Society, 25(7), 678-687. Cambridge University Press
- Publication Year :
- 2019
-
Abstract
- Objective:Parkinson’s disease with mild cognitive impairment (PD-MCI) is a risk factor for progression to PD dementia (PDD) at a later stage of the disease. The consensus criteria of PD-MCI use a traditional test-by-test normative comparison. The aim of this study was to investigate whether a new multivariate statistical method provides a more sensitive tool for predicting dementia status at 3- and 5-year follow-ups. This method allows a formal evaluation of a patient’s profile of test scores given a large aggregated database with regression-based norms.Method:The cognitive test results of 123 newly diagnosed PD patients from a previously published longitudinal study were analyzed with three different methods. First, the PD-MCI criteria were applied in the traditional way. Second, the PD-MCI criteria were applied using the large aggregated normative database. Last, multivariate normative comparisons (MNCs) were made using the same aggregated normative database. The outcome variable was progression to dementia within 3 and 5 years.Results:The MNC was characterized by higher sensitivity and higher specificity in predicting progression to PDD at follow-up than the two PD-MCI criteria methods, although the difference in classification accuracy did not reach statistical significance.Conclusion:We conclude that MNCs could allow for a more accurate prediction of PDD than the traditional PD-MCI criteria, because there are encouraging trends in both increased sensitivity and increased specificity. (JINS, 2019,25, 678–687)
- Subjects :
- Male
Multivariate statistics
Longitudinal study
Sensitivity and Specificity
03 medical and health sciences
0302 clinical medicine
Statistical significance
mental disorders
Medicine
Dementia
Humans
Cognitive Dysfunction
Longitudinal Studies
Risk factor
030304 developmental biology
Aged
0303 health sciences
business.industry
General Neuroscience
Parkinson Disease
Middle Aged
medicine.disease
Prognosis
Regression
Cognitive test
Psychiatry and Mental health
Clinical Psychology
Data Interpretation, Statistical
Multivariate Analysis
Disease Progression
Normative
Female
Neurology (clinical)
business
030217 neurology & neurosurgery
Clinical psychology
Subjects
Details
- Language :
- English
- ISSN :
- 13556177
- Volume :
- 25
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Journal of the International Neuropsychological Society
- Accession number :
- edsair.doi.dedup.....d6c46ff749a3b5f4e8e4bcce7e0a0912