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Pneumocystis jiroveciidihydropteroate synthase (DHPS) genotypes in non-HIV-immunocompromised patients: a tertiary care reference health centre study
- Source :
- Medical Mycology. 49:167-171
- Publication Year :
- 2011
- Publisher :
- Oxford University Press (OUP), 2011.
-
Abstract
- Studies on Pneumocystis jirovecii dihydropteroate synthase (DHPS) genotypes among non-HIV immunocompromised patients from developing countries are rare. In the present prospective investigation, 24 (11.8%) cases were found to be positive for Pneumocystis jirovecii out of 203 non-HIV patients with a clinical suspicion of Pneumocystis pneumonia (PCP). Dihydropteroate synthase (DHPS) genotype 1 (Thr55+Pro57) was noted in 95.8% P. jirovecii isolates in the present study in contrast to only 4.1% of patients with DHPS genotype 4 (Thr55Ala + Pro57Ser).
- Subjects :
- Adult
Male
Adolescent
Genotype
DHPS
Pneumocystis carinii
Pneumocystis pneumonia
Tertiary care
Immunocompromised Host
Young Adult
parasitic diseases
medicine
Humans
Pneumocystis jirovecii
Prospective Studies
Child
Prospective cohort study
Dihydropteroate Synthase
biology
business.industry
Pneumonia, Pneumocystis
Infant
General Medicine
Middle Aged
biology.organism_classification
medicine.disease
Virology
Hospitals
Pneumonia
Infectious Diseases
Amino Acid Substitution
Child, Preschool
Female
Dihydropteroate synthase
business
Subjects
Details
- ISSN :
- 14602709 and 13693786
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Medical Mycology
- Accession number :
- edsair.doi.dedup.....d6c243ab5bce136010ca8ad64a1dc55b