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Cue-induced striatal activity in frequent cannabis users independently predicts cannabis problem severity three years later
- Source :
- Journal of Psychopharmacology, 30(2), 152-158. SAGE Publications Ltd, Journal of psychopharmacology (Oxford, England), 30(2), 152-158. SAGE Publications Ltd
- Publication Year :
- 2016
-
Abstract
- Cannabis is the most frequently used illicit drug worldwide, but little is known about the mechanisms underlying continued cannabis use. Cue-reactivity (the physical, psychological, behavioural and neural reaction to substance-related cues) might be related to continued cannabis use. In this 3-year prospective neuroimaging study we investigated whether cannabis cue-induced brain activity predicted continued cannabis use and associated problem severity 3 years later. In addition, baseline brain activations were compared between dependent and non-dependent cannabis users at follow-up. Analyses were focussed on brain areas known to be important in cannabis cue-reactivity: anterior cingulate cortex, orbitofrontal cortex, ventral tegmental area, amygdala and striatum. At baseline, 31 treatment-naive frequent cannabis users performed a cue-reactivity functional magnetic resonance imaging task. Of these participants, 23 completed the 3-year follow-up. None of the cue-induced region of interest activations predicted the amount of cannabis use at follow-up. However, cue-induced activation in the left striatum (putamen) significantly and independently predicted problem severity at follow-up ( p < 0.001) as assessed with the Cannabis Use Disorder Identification Test. Also, clinically dependent cannabis users at follow-up showed higher baseline activation at trend level in the left striatum compared with non-dependent users. This indicates that neural cue-reactivity in the dorsal striatum is an independent predictor of cannabis use-related problems. Given the relatively small sample size, these results are preliminary and should be replicated in larger samples of cannabis users.
- Subjects :
- cannabis
Adult
Male
medicine.medical_specialty
Marijuana Abuse
Brain activity and meditation
striatum
media_common.quotation_subject
cannabis use disorder
Addiction
Marijuana Smoking
Audiology
Severity of Illness Index
03 medical and health sciences
Young Adult
0302 clinical medicine
SDG 3 - Good Health and Well-being
medicine
Humans
Pharmacology (medical)
Prospective Studies
Psychiatry
Anterior cingulate cortex
media_common
Pharmacology
medicine.diagnostic_test
biology
Putamen
fMRI
cue-reactivity
Brain
biology.organism_classification
Magnetic Resonance Imaging
Corpus Striatum
030227 psychiatry
Psychiatry and Mental health
medicine.anatomical_structure
Cue reactivity
Orbitofrontal cortex
Female
Cannabis
Cues
Functional magnetic resonance imaging
Psychology
030217 neurology & neurosurgery
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 02698811
- Database :
- OpenAIRE
- Journal :
- Journal of Psychopharmacology, 30(2), 152-158. SAGE Publications Ltd, Journal of psychopharmacology (Oxford, England), 30(2), 152-158. SAGE Publications Ltd
- Accession number :
- edsair.doi.dedup.....d6b3e58887f9f68dee91bf4bb8e29a5e