Back to Search
Start Over
The Molecular and Cellular Effect of Homocysteine Metabolism Imbalance on Human Health
- Source :
- International Journal of Molecular Sciences, Vol 17, Iss 10, p 1733 (2016), International Journal of Molecular Sciences
- Publication Year :
- 2016
- Publisher :
- MDPI AG, 2016.
-
Abstract
- Homocysteine (Hcy) is a sulfur-containing non-proteinogenic amino acid derived in methionine metabolism. The increased level of Hcy in plasma, hyperhomocysteinemia, is considered to be an independent risk factor for cardio and cerebrovascular diseases. However, it is still not clear if Hcy is a marker or a causative agent of diseases. More and more research data suggest that Hcy is an important indicator for overall health status. This review represents the current understanding of molecular mechanism of Hcy metabolism and its link to hyperhomocysteinemia-related pathologies in humans. The aberrant Hcy metabolism could lead to the redox imbalance and oxidative stress resulting in elevated protein, nucleic acid and carbohydrate oxidation and lipoperoxidation, products known to be involved in cytotoxicity. Additionally, we examine the role of Hcy in thiolation of proteins, which results in their molecular and functional modifications. We also highlight the relationship between the imbalance in Hcy metabolism and pathogenesis of diseases, such as cardiovascular diseases, neurological and psychiatric disorders, chronic kidney disease, bone tissue damages, gastrointestinal disorders, cancer, and congenital defects.
- Subjects :
- cellular toxicity
0301 basic medicine
Homocysteine
Gastrointestinal Diseases
Health Status
Review
Disease
medicine.disease_cause
homocysteine metabolism
lcsh:Chemistry
Pathogenesis
chemistry.chemical_compound
Risk Factors
Neoplasms
oxidative stress
lcsh:QH301-705.5
Spectroscopy
General Medicine
Computer Science Applications
Cardiovascular Diseases
Kidney Diseases
Bone Diseases
Oxidation-Reduction
Hyperhomocysteinemia
medicine.medical_specialty
hyperhomocysteimenia
Carbohydrate metabolism
Biology
Catalysis
Inorganic Chemistry
03 medical and health sciences
Internal medicine
medicine
Humans
Physical and Theoretical Chemistry
Molecular Biology
disease
Organic Chemistry
Cancer
medicine.disease
Cerebrovascular Disorders
030104 developmental biology
Endocrinology
lcsh:Biology (General)
lcsh:QD1-999
chemistry
Oxidative stress
Kidney disease
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....d6b03fba5fdcacba17ad6966014593c4