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A network analysis to identify mediators of germline-driven differences in breast cancer prognosis
- Source :
- Repisalud, Instituto de Salud Carlos III (ISCIII), Nature Communications, Nature Communications, 11(1):312. Nature Publishing Group, Escala-Garcia, M, Abraham, J, Andrulis, I L, Anton-Culver, H, Arndt, V, Ashworth, A, Auer, P L, Auvinen, P, Beckmann, M W, Beesley, J, Behrens, S, Benitez, J, Bermisheva, M, Blomqvist, C, Blot, W, Bogdanova, N V, Bojesen, S E, Bolla, M K, Børresen-Dale, A-L, Brauch, H, Brenner, H, Brucker, S Y, Burwinkel, B, Caldas, C, Canzian, F, Chang-Claude, J, Chanock, S J, Chin, S-F, Clarke, C L, Couch, F J, Cox, A, Cross, S S, Czene, K, Daly, M B, Dennis, J, Devilee, P, Dunn, J A, Dunning, A M, Dwek, M, Earl, H M, Eccles, D M, Eliassen, A H, Ellberg, C, Evans, D G, Fasching, P A, Figueroa, J, Flyger, H, Gago-Dominguez, M, Gapstur, S M, García-Closas, M, García-Sáenz, J A, Gaudet, M M, George, A, Giles, G G, Goldgar, D E, González-Neira, A, Grip, M, Guénel, P, Guo, Q, Haiman, C A, Håkansson, N, Hamann, U, Harrington, P A, Hiller, L, Hooning, M J, Hopper, J L, Howell, A, Huang, C-S, Huang, G, Hunter, D J, Jakubowska, A, John, E M, Kaaks, R, Kapoor, P M, Keeman, R, Kitahara, C M, Koppert, L B, Kraft, P, Kristensen, V N, Lambrechts, D, Le Marchand, L, Lejbkowicz, F, Lindblom, A, Lubiński, J, Mannermaa, A, Manoochehri, M, Manoukian, S, Margolin, S, Martinez, M E, Maurer, T, Mavroudis, D, Meindl, A, Milne, R L, Mulligan, A M, Neuhausen, S L, Nevanlinna, H, Newman, W G, Olshan, A F, Olson, J E, Olsson, H, Orr, N, Peterlongo, P, Petridis, C, Prentice, R L, Presneau, N, Punie, K, Ramachandran, D, Rennert, G, Romero, A, Sachchithananthan, M, Saloustros, E, Sawyer, E J, Schmutzler, R K, Schwentner, L, Scott, C, Simard, J, Sohn, C, Southey, M C, Swerdlow, A J, Tamimi, R M, Tapper, W J, Teixeira, M R, Terry, M B, Thorne, H, Tollenaar, R A E M, Tomlinson, I, Troester, M A, Truong, T, Turnbull, C, Vachon, C M, van der Kolk, L E, Wang, Q, Winqvist, R, Wolk, A, Yang, X R, Ziogas, A, Pharoah, P D P, Hall, P, Wessels, L F A, Chenevix-Trench, G, Bader, G D, Dörk, T, Easton, D F, Canisius, S & Schmidt, M K 2020, ' A network analysis to identify mediators of germline-driven differences in breast cancer prognosis ', Nature Communications, vol. 11, no. 1, pp. 312 . https://doi.org/10.1038/s41467-019-14100-6, Escala-Garcia, M, Abraham, J, Andrulis, I L, Anton-Culver, H, Arndt, V, Ashworth, A, Auer, P L, Auvinen, P, Beckmann, M W, Beesley, J, Behrens, S, Benitez, J, Bermisheva, M, Blomqvist, C, Blot, W, Bogdanova, N V, Bojesen, S E, Bolla, M K, Børresen-Dale, A-L, Brauch, H, Brenner, H, Brucker, S Y, Burwinkel, B, Caldas, C, Canzian, F, Chang-Claude, J, Chanock, S J, Chin, S-F, Clarke, C L, Couch, F J, Cox, A, Cross, S S, Czene, K, Daly, M B, Dennis, J, Devilee, P, Dunn, J A, Dunning, A M, Dwek, M, Earl, H M, Eccles, D M, Eliassen, A H, Ellberg, C, Evans, D G, Fasching, P A, Figueroa, J, Flyger, H, Gago-Dominguez, M, Gapstur, S M, García-Closas, M, García-Sáenz, J A, Gaudet, M M, George, A, Giles, G G, Goldgar, D E, González-Neira, A, Grip, M, Guénel, P, Guo, Q, Haiman, C A, Håkansson, N, Hamann, U, Harrington, P A, Hiller, L, Hooning, M J, Hopper, J L, Howell, A, Huang, C-S, Huang, G, Hunter, D J, Jakubowska, A, John, E M, Kaaks, R, Kapoor, P M, Keeman, R, Kitahara, C M, Koppert, L B, Kraft, P, Kristensen, V N, Lambrechts, D, Le Marchand, L, Lejbkowicz, F, Lindblom, A, Lubiński, J, Mannermaa, A, Manoochehri, M, Manoukian, S, Margolin, S, Martinez, M E, Maurer, T, Mavroudis, D, Meindl, A, Milne, R L, Mulligan, A M, Neuhausen, S L, Nevanlinna, H, Newman, W G, Olshan, A F, Olson, J E, Olsson, H, Orr, N, Peterlongo, P, Petridis, C, Prentice, R L, Presneau, N, Punie, K, Ramachandran, D, Rennert, G, Romero, A, Sachchithananthan, M, Saloustros, E, Sawyer, E J, Schmutzler, R K, Schwentner, L, Scott, C, Simard, J, Sohn, C, Southey, M C, Swerdlow, A J, Tamimi, R M, Tapper, W J, Teixeira, M R, Terry, M B, Thorne, H, Tollenaar, R A E M, Tomlinson, I, Troester, M A, Truong, T, Turnbull, C, Vachon, C M, van der Kolk, L E, Winqvist, R, Wolk, A, Yang, X R, Ziogas, A, Pharoah, P D P, Hall, P, Wessels, L F A, Chenevix-Trench, G, Bader, G D, Dörk, T, Easton, D F, Canisius, S & Schmidt, M K 2020, ' A network analysis to identify mediators of germline-driven differences in breast cancer prognosis ', Nature Communications, vol. 11, no. 1, 312 . https://doi.org/10.1038/s41467-019-14100-6, Nature Communications, 11(1), Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020), Nature Communications, 11(1). NATURE PUBLISHING GROUP, Escala-garcia, M, Abraham, J, Andrulis, I L, Anton-culver, H, Arndt, V, Ashworth, A, Auer, P L, Auvinen, P, Beckmann, M W, Beesley, J, Behrens, S, Benitez, J, Bermisheva, M, Blomqvist, C, Blot, W, Bogdanova, N V, Bojesen, S E, Bolla, M K, Børresen-dale, A, Brauch, H, Brenner, H, Brucker, S Y, Burwinkel, B, Caldas, C, Canzian, F, Chang-claude, J, Chanock, S J, Chin, S, Clarke, C L, Couch, F J, Cox, A, Cross, S S, Czene, K, Daly, M B, Dennis, J, Devilee, P, Dunn, J A, Dunning, A M, Dwek, M, Earl, H M, Eccles, D M, Eliassen, A H, Ellberg, C, Evans, D G, Fasching, P A, Figueroa, J, Flyger, H, Gago-dominguez, M, Gapstur, S M, García-closas, M, García-sáenz, J A, Gaudet, M M, George, A, Giles, G G, Goldgar, D E, González-neira, A, Grip, M, Guénel, P, Guo, Q, Haiman, C A, Håkansson, N, Hamann, U, Harrington, P A, Hiller, L, Hooning, M J, Hopper, J L, Howell, A, Huang, C, Huang, G, Hunter, D J, Jakubowska, A, John, E M, Kaaks, R, Kapoor, P M, Keeman, R, Kitahara, C M, Koppert, L B, Kraft, P, Kristensen, V N, Lambrechts, D, Le Marchand, L, Lejbkowicz, F, Lindblom, A, Lubiński, J, Mannermaa, A, Manoochehri, M, Manoukian, S, Margolin, S, Martinez, M E, Maurer, T, Mavroudis, D, Meindl, A, Milne, R L, Mulligan, A M, Neuhausen, S L, Nevanlinna, H, Newman, W G, Olshan, A F, Olson, J E, Olsson, H, Orr, N, Peterlongo, P, Petridis, C, Prentice, R L, Presneau, N, Punie, K, Ramachandran, D, Rennert, G, Romero, A, Sachchithananthan, M, Saloustros, E, Sawyer, E J, Schmutzler, R K, Schwentner, L, Scott, C, Simard, J, Sohn, C, Southey, M C, Swerdlow, A J, Tamimi, R M, Tapper, W J, Teixeira, M R, Terry, M B, Thorne, H, Tollenaar, R A E M, Tomlinson, I, Troester, M A, Truong, T, Turnbull, C, Vachon, C M, Van Der Kolk, L E, Wang, Q, Winqvist, R, Wolk, A, Yang, X R, Ziogas, A, Pharoah, P D P, Hall, P, Wessels, L F A, Chenevix-trench, G, Bader, G D, Dörk, T, Easton, D F, Canisius, S & Schmidt, M K 2020, ' A network analysis to identify mediators of germline-driven differences in breast cancer prognosis ', Nature Communications, vol. 11, no. 1 . https://doi.org/10.1038/s41467-019-14100-6
- Publication Year :
- 2020
-
Abstract
- Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies ~7.3 million variants in 84,457 breast cancer patients in relation to breast cancer survival and confirms the results on 12,381 independent patients. Aggregating the prognostic effects of genetic variants across multiple genes, we identify four gene modules associated with survival in estrogen receptor (ER)-negative and one in ER-positive disease. The modules show biological enrichment for cancer-related processes such as G-alpha signaling, circadian clock, angiogenesis, and Rho-GTPases in apoptosis.<br />In breast cancer the contribution of different genetic variants to disease heritability is complex and not fully understood. Here, the authors present a network-based analysis in 84,567 patients studying ~7.3 million variants, identifying gene modules associated with breast cancer survival.
- Subjects :
- 0301 basic medicine
PTEN
GTP-Binding Protein alpha Subunits, Gq-G11/genetics
45/43
Gene regulatory network
General Physics and Astronomy
Estrogen receptor
Genome-wide association study
Apoptosis
Disease
CIRCADIAN CLOCK
VARIANTS
Bioinformatics
Genome-wide association studies
Germline
Metastasis
PATHWAY
0302 clinical medicine
Breast cancer
3123 Gynaecology and paediatrics
Gene Regulatory Networks
lcsh:Science
Multidisciplinary
TUMOR-GROWTH
Receptors, Estrogen/genetics
Prognosis
GTP-Binding Protein alpha Subunits
3. Good health
Multidisciplinary Sciences
Receptors, Estrogen
030220 oncology & carcinogenesis
Medical genetics
Science & Technology - Other Topics
Female
Medical Genetics
Signal Transduction
medicine.medical_specialty
Genotype
Science
3122 Cancers
631/208/205/2138
Breast Neoplasms
Biology
Breast Neoplasms/genetics
General Biochemistry, Genetics and Molecular Biology
Article
03 medical and health sciences
PROTEIN-COUPLED RECEPTORS
SDG 3 - Good Health and Well-being
Circadian Clocks
medicine
Humans
GENOME-WIDE ASSOCIATION
Medicinsk genetik
Science & Technology
45
Genetic Variation
Computational Biology
General Chemistry
medicine.disease
GENE
Computational biology and bioinformatics
030104 developmental biology
Germ Cells
GTP-Binding Protein alpha Subunits/genetics
METASTASIS
GTP-Binding Protein alpha Subunits, Gq-G11
692/4028/67/1347
lcsh:Q
CELL-GROWTH
631/114
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Database :
- OpenAIRE
- Journal :
- Repisalud, Instituto de Salud Carlos III (ISCIII), Nature Communications, Nature Communications, 11(1):312. Nature Publishing Group, Escala-Garcia, M, Abraham, J, Andrulis, I L, Anton-Culver, H, Arndt, V, Ashworth, A, Auer, P L, Auvinen, P, Beckmann, M W, Beesley, J, Behrens, S, Benitez, J, Bermisheva, M, Blomqvist, C, Blot, W, Bogdanova, N V, Bojesen, S E, Bolla, M K, Børresen-Dale, A-L, Brauch, H, Brenner, H, Brucker, S Y, Burwinkel, B, Caldas, C, Canzian, F, Chang-Claude, J, Chanock, S J, Chin, S-F, Clarke, C L, Couch, F J, Cox, A, Cross, S S, Czene, K, Daly, M B, Dennis, J, Devilee, P, Dunn, J A, Dunning, A M, Dwek, M, Earl, H M, Eccles, D M, Eliassen, A H, Ellberg, C, Evans, D G, Fasching, P A, Figueroa, J, Flyger, H, Gago-Dominguez, M, Gapstur, S M, García-Closas, M, García-Sáenz, J A, Gaudet, M M, George, A, Giles, G G, Goldgar, D E, González-Neira, A, Grip, M, Guénel, P, Guo, Q, Haiman, C A, Håkansson, N, Hamann, U, Harrington, P A, Hiller, L, Hooning, M J, Hopper, J L, Howell, A, Huang, C-S, Huang, G, Hunter, D J, Jakubowska, A, John, E M, Kaaks, R, Kapoor, P M, Keeman, R, Kitahara, C M, Koppert, L B, Kraft, P, Kristensen, V N, Lambrechts, D, Le Marchand, L, Lejbkowicz, F, Lindblom, A, Lubiński, J, Mannermaa, A, Manoochehri, M, Manoukian, S, Margolin, S, Martinez, M E, Maurer, T, Mavroudis, D, Meindl, A, Milne, R L, Mulligan, A M, Neuhausen, S L, Nevanlinna, H, Newman, W G, Olshan, A F, Olson, J E, Olsson, H, Orr, N, Peterlongo, P, Petridis, C, Prentice, R L, Presneau, N, Punie, K, Ramachandran, D, Rennert, G, Romero, A, Sachchithananthan, M, Saloustros, E, Sawyer, E J, Schmutzler, R K, Schwentner, L, Scott, C, Simard, J, Sohn, C, Southey, M C, Swerdlow, A J, Tamimi, R M, Tapper, W J, Teixeira, M R, Terry, M B, Thorne, H, Tollenaar, R A E M, Tomlinson, I, Troester, M A, Truong, T, Turnbull, C, Vachon, C M, van der Kolk, L E, Wang, Q, Winqvist, R, Wolk, A, Yang, X R, Ziogas, A, Pharoah, P D P, Hall, P, Wessels, L F A, Chenevix-Trench, G, Bader, G D, Dörk, T, Easton, D F, Canisius, S & Schmidt, M K 2020, ' A network analysis to identify mediators of germline-driven differences in breast cancer prognosis ', Nature Communications, vol. 11, no. 1, pp. 312 . https://doi.org/10.1038/s41467-019-14100-6, Escala-Garcia, M, Abraham, J, Andrulis, I L, Anton-Culver, H, Arndt, V, Ashworth, A, Auer, P L, Auvinen, P, Beckmann, M W, Beesley, J, Behrens, S, Benitez, J, Bermisheva, M, Blomqvist, C, Blot, W, Bogdanova, N V, Bojesen, S E, Bolla, M K, Børresen-Dale, A-L, Brauch, H, Brenner, H, Brucker, S Y, Burwinkel, B, Caldas, C, Canzian, F, Chang-Claude, J, Chanock, S J, Chin, S-F, Clarke, C L, Couch, F J, Cox, A, Cross, S S, Czene, K, Daly, M B, Dennis, J, Devilee, P, Dunn, J A, Dunning, A M, Dwek, M, Earl, H M, Eccles, D M, Eliassen, A H, Ellberg, C, Evans, D G, Fasching, P A, Figueroa, J, Flyger, H, Gago-Dominguez, M, Gapstur, S M, García-Closas, M, García-Sáenz, J A, Gaudet, M M, George, A, Giles, G G, Goldgar, D E, González-Neira, A, Grip, M, Guénel, P, Guo, Q, Haiman, C A, Håkansson, N, Hamann, U, Harrington, P A, Hiller, L, Hooning, M J, Hopper, J L, Howell, A, Huang, C-S, Huang, G, Hunter, D J, Jakubowska, A, John, E M, Kaaks, R, Kapoor, P M, Keeman, R, Kitahara, C M, Koppert, L B, Kraft, P, Kristensen, V N, Lambrechts, D, Le Marchand, L, Lejbkowicz, F, Lindblom, A, Lubiński, J, Mannermaa, A, Manoochehri, M, Manoukian, S, Margolin, S, Martinez, M E, Maurer, T, Mavroudis, D, Meindl, A, Milne, R L, Mulligan, A M, Neuhausen, S L, Nevanlinna, H, Newman, W G, Olshan, A F, Olson, J E, Olsson, H, Orr, N, Peterlongo, P, Petridis, C, Prentice, R L, Presneau, N, Punie, K, Ramachandran, D, Rennert, G, Romero, A, Sachchithananthan, M, Saloustros, E, Sawyer, E J, Schmutzler, R K, Schwentner, L, Scott, C, Simard, J, Sohn, C, Southey, M C, Swerdlow, A J, Tamimi, R M, Tapper, W J, Teixeira, M R, Terry, M B, Thorne, H, Tollenaar, R A E M, Tomlinson, I, Troester, M A, Truong, T, Turnbull, C, Vachon, C M, van der Kolk, L E, Winqvist, R, Wolk, A, Yang, X R, Ziogas, A, Pharoah, P D P, Hall, P, Wessels, L F A, Chenevix-Trench, G, Bader, G D, Dörk, T, Easton, D F, Canisius, S & Schmidt, M K 2020, ' A network analysis to identify mediators of germline-driven differences in breast cancer prognosis ', Nature Communications, vol. 11, no. 1, 312 . https://doi.org/10.1038/s41467-019-14100-6, Nature Communications, 11(1), Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020), Nature Communications, 11(1). NATURE PUBLISHING GROUP, Escala-garcia, M, Abraham, J, Andrulis, I L, Anton-culver, H, Arndt, V, Ashworth, A, Auer, P L, Auvinen, P, Beckmann, M W, Beesley, J, Behrens, S, Benitez, J, Bermisheva, M, Blomqvist, C, Blot, W, Bogdanova, N V, Bojesen, S E, Bolla, M K, Børresen-dale, A, Brauch, H, Brenner, H, Brucker, S Y, Burwinkel, B, Caldas, C, Canzian, F, Chang-claude, J, Chanock, S J, Chin, S, Clarke, C L, Couch, F J, Cox, A, Cross, S S, Czene, K, Daly, M B, Dennis, J, Devilee, P, Dunn, J A, Dunning, A M, Dwek, M, Earl, H M, Eccles, D M, Eliassen, A H, Ellberg, C, Evans, D G, Fasching, P A, Figueroa, J, Flyger, H, Gago-dominguez, M, Gapstur, S M, García-closas, M, García-sáenz, J A, Gaudet, M M, George, A, Giles, G G, Goldgar, D E, González-neira, A, Grip, M, Guénel, P, Guo, Q, Haiman, C A, Håkansson, N, Hamann, U, Harrington, P A, Hiller, L, Hooning, M J, Hopper, J L, Howell, A, Huang, C, Huang, G, Hunter, D J, Jakubowska, A, John, E M, Kaaks, R, Kapoor, P M, Keeman, R, Kitahara, C M, Koppert, L B, Kraft, P, Kristensen, V N, Lambrechts, D, Le Marchand, L, Lejbkowicz, F, Lindblom, A, Lubiński, J, Mannermaa, A, Manoochehri, M, Manoukian, S, Margolin, S, Martinez, M E, Maurer, T, Mavroudis, D, Meindl, A, Milne, R L, Mulligan, A M, Neuhausen, S L, Nevanlinna, H, Newman, W G, Olshan, A F, Olson, J E, Olsson, H, Orr, N, Peterlongo, P, Petridis, C, Prentice, R L, Presneau, N, Punie, K, Ramachandran, D, Rennert, G, Romero, A, Sachchithananthan, M, Saloustros, E, Sawyer, E J, Schmutzler, R K, Schwentner, L, Scott, C, Simard, J, Sohn, C, Southey, M C, Swerdlow, A J, Tamimi, R M, Tapper, W J, Teixeira, M R, Terry, M B, Thorne, H, Tollenaar, R A E M, Tomlinson, I, Troester, M A, Truong, T, Turnbull, C, Vachon, C M, Van Der Kolk, L E, Wang, Q, Winqvist, R, Wolk, A, Yang, X R, Ziogas, A, Pharoah, P D P, Hall, P, Wessels, L F A, Chenevix-trench, G, Bader, G D, Dörk, T, Easton, D F, Canisius, S & Schmidt, M K 2020, ' A network analysis to identify mediators of germline-driven differences in breast cancer prognosis ', Nature Communications, vol. 11, no. 1 . https://doi.org/10.1038/s41467-019-14100-6
- Accession number :
- edsair.doi.dedup.....d6af4aa59eb42af784bdbac679e10763