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Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf
- Source :
- Bioorganic and Medicinal Chemistry Letters, Bioorganic and Medicinal Chemistry Letters, Elsevier, 2005, 15 (10), pp.2637-40. ⟨10.1016/j.bmcl.2005.03.021⟩
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- International audience; Bioassay-guided fractionation of the EtOH extract of the stem bark of Funtumia elastica resulted in the isolation of four steroidal alkaloids, holarrhetine (1), conessine (2), holarrhesine (3) and isoconessimine (4). Their structures were determined on the basis of 1D- and 2D-NMR techniques and mass spectrometry. Compounds 1-4 exhibited in vitro antiplasmodial activity against the chloroquine-resistant strain FcB1 of Plasmodium falciparum with IC50 values ranging from 0.97 to 3.39 microM. They showed weak cytotoxicity against a rat cell line L-6 with IC50 values ranging from 5.13 to 36.55 microM.
- Subjects :
- Spectrometry, Mass, Electrospray Ionization
Magnetic Resonance Spectroscopy
Stereochemistry
Plasmodium falciparum
Clinical Biochemistry
Pharmaceutical Science
Fractionation
Pharmacognosy
MESH: Spectrometry, Mass, Electrospray Ionization
Biochemistry
Antimalarials
chemistry.chemical_compound
Alkaloids
MESH: Apocynaceae
MESH: Alkaloids
Drug Discovery
Animals
MESH: Animals
[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology
Cytotoxicity
Molecular Biology
MESH: Plasmodium falciparum
Stem bark
Traditional medicine
biology
Apocynaceae
MESH: Magnetic Resonance Spectroscopy
Chemistry
Alkaloid
Organic Chemistry
Biological activity
General Medicine
biology.organism_classification
MESH: Antimalarials
Conessine
Funtumia elastica
visual_art
visual_art.visual_art_medium
Molecular Medicine
Bark
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....d6a5ff0494266c8a8af332a072d4e321