Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf

Authors :: Guédé Noël Zirihi
Bernard Bodo
Philippe Grellier
Frederick Guede-Guina
Lengo Mambu
Molécules de Communication et Adaptation des Micro-Organismes (MCAM)
Centre National de la Recherche Scientifique (CNRS)-Muséum national d'Histoire naturelle (MNHN)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Laboratoire de chimie et biochimie des substances naturelles
Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS)
Source :: Bioorganic and Medicinal Chemistry Letters, Bioorganic and Medicinal Chemistry Letters, Elsevier, 2005, 15 (10), pp.2637-40. ⟨10.1016/j.bmcl.2005.03.021⟩
Publication Year :: 2005
Publisher :: Elsevier BV, 2005.
Abstract: International audience; Bioassay-guided fractionation of the EtOH extract of the stem bark of Funtumia elastica resulted in the isolation of four steroidal alkaloids, holarrhetine (1), conessine (2), holarrhesine (3) and isoconessimine (4). Their structures were determined on the basis of 1D- and 2D-NMR techniques and mass spectrometry. Compounds 1-4 exhibited in vitro antiplasmodial activity against the chloroquine-resistant strain FcB1 of Plasmodium falciparum with IC50 values ranging from 0.97 to 3.39 microM. They showed weak cytotoxicity against a rat cell line L-6 with IC50 values ranging from 5.13 to 36.55 microM.

Tools