Back to Search
Start Over
Cutaneous silent period recordings in demyelinating and axonal polyneuropathies
- Publication Year :
- 2014
-
Abstract
- Objective To investigate the cutaneous silent period (CSP), a spinal inhibitory reflex mainly mediated by A-delta fibres, in demyelinating and axonal polyneuropathy (PNP) and evaluate whether CSP parameters differ between patients with and without neuropathic pain. Methods Eighty-four patients with demyelinating PNP, 178 patients with axonal PNP and 265 controls underwent clinical examination, DN4 questionnaire, standard nerve conduction study, motor-root stimulation and CSP recordings from abductor digiti minimi. We calculated the afferent conduction time of CSP (a-CSP time) with the formula: CSP latency − root motor evoked potential latency. Results In the demyelinating PNP group the a-CSP time was significantly longer; in the axonal PNP group, CSP duration was shorter than the demyelinating group ( p = 0.010) and controls ( p = 0.001). CSP parameters were not different between patients with and without neuropathic pain. Conclusions The abnormality of a-CSP time in the demyelinating PNP group suggests the crucial role of A-delta fibres in the mechanism of CSP; the shorter CSP duration in the axonal PNP group supports the strong influence of the number of axons on this parameter. Our study suggests that neuropathic pain could be related to pathophysiological mechanisms differing from mere A-delta fibre loss. Significance CSP evaluation is effective in detecting A-delta fibre dysfunction in axonal as well as demyelinating PNP.
- Subjects :
- Male
animal structures
Neural Conduction
Stimulation
Inhibitory postsynaptic potential
complex mixtures
Cohort Studies
Polyneuropathies
Physiology (medical)
parasitic diseases
Medicine
Humans
heterocyclic compounds
Evoked potential
Aged
medicine.diagnostic_test
business.industry
Electromyography
fungi
Middle Aged
Evoked Potentials, Motor
Sensory Systems
Pathophysiology
Axons
Neurology
Anesthesia
Neuropathic pain
Nerve conduction study
Reflex
Silent period
Female
Neurology (clinical)
business
Neuroscience
Cutaneous silent period A-delta fibres Axonal polyneuropathy Demyelinating polyneuropathy Neuropathic pain
Demyelinating Diseases
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....d69d7047006d4a7514a2decc0b7e82e5