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Neoantigens encoded in the cancer genome
- Source :
- Current opinion in immunology. 41
- Publication Year :
- 2016
-
Abstract
- Somatic mutations in the genome represent one of the major drivers of malignancy. However, non-synonymous mutations are also a source of mutated peptides that are presented by HLA molecules to induce protective CD4 and CD8 T cell responses. Consistent with this notion, the mutation burden of a tumor is correlated with local immunity as well as outcome of therapy and patient survival. Furthermore, neoantigen-specific T cells appear sufficient to control tumors prophylactically and therapeutically. While the role of neoantigens as a determinant of the foreignness of human cancers is now well established, major questions, including the relative importance of clonal vs subclonal neoantigens, and CD4 vs CD8 T cells, remain unanswered. We expect continued animal studies to address some of the open issues and ongoing clinical trials to establish the utility of therapeutic strategies to enhance neoantigen-specific T cell responses in human cancer.
- Subjects :
- 0301 basic medicine
Mutation
Genome
integumentary system
Somatic cell
T cell
Immunology
Biology
medicine.disease_cause
Malignancy
medicine.disease
03 medical and health sciences
030104 developmental biology
medicine.anatomical_structure
Antigen
Antigens, Neoplasm
Neoplasms
medicine
Immunology and Allergy
Cytotoxic T cell
Animals
Humans
Animal studies
Subjects
Details
- ISSN :
- 18790372
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Current opinion in immunology
- Accession number :
- edsair.doi.dedup.....d69d4ee38bf7a92fe4d7219c87e6e854