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Candidatus Mycoplasma haemohominis in Human, Japan

Authors :
Ryo Yanai
Tsuyoshi Nakamaki
Takahiro Takuma
Norimichi Hattori
Yoshihito Niki
Tsuyoshi Sekizuka
Sho Ishii
Hiroyuki Watanabe
Makoto Kuroda
Takayoshi Ito
T. Tokunaga
Harutaka Katano
Nana Arai
Hideki Hasegawa
Junichi Eguchi
Yoko Miura
Norihiro Nomura
Takaji Wakita
Source :
Emerging Infectious Diseases, Emerging Infectious Diseases, Vol 26, Iss 1, Pp 11-19 (2020)
Publication Year :
2020
Publisher :
Centers for Disease Control and Prevention (CDC), 2020.

Abstract

Hemotropic mycoplasmas are common pathogens in animals, but it remains unclear what role these pathogens play in human infections. We report clinical and biologic characterization of Candidatus Mycoplasma haemohominis infection in a 42-year-old man in Japan. The patient had severe hemophagocytic syndrome 1 month after an accidental needlestick injury. Metagenomic deep sequencing identified Candidatus M. haemohominis and determined its draft genome for an isolate from serum of the patient. A high copy number of the Candidatus M. haemohominis genome was detected in serum and bone marrow samples. Electron microscopy examination showed morphologic characteristics of Candidatus M. haemohominis. Levofloxacin monotherapy induced resistance caused by a gyrase A gene mutation in the quinolone resistance–determining region, but a combination treatment with moxifloxacin and minocycline was effective. We identified Candidatus M. haemohominis in a patient who had life-threatening symptoms related to multiple organ infection. Human infection with this mycoplasma might occur more frequently than has been generally recognized.

Details

ISSN :
10806059 and 10806040
Volume :
26
Database :
OpenAIRE
Journal :
Emerging Infectious Diseases
Accession number :
edsair.doi.dedup.....d690710383400b6fe9511125483aaba5