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Candidatus Mycoplasma haemohominis in Human, Japan
- Source :
- Emerging Infectious Diseases, Emerging Infectious Diseases, Vol 26, Iss 1, Pp 11-19 (2020)
- Publication Year :
- 2020
- Publisher :
- Centers for Disease Control and Prevention (CDC), 2020.
-
Abstract
- Hemotropic mycoplasmas are common pathogens in animals, but it remains unclear what role these pathogens play in human infections. We report clinical and biologic characterization of Candidatus Mycoplasma haemohominis infection in a 42-year-old man in Japan. The patient had severe hemophagocytic syndrome 1 month after an accidental needlestick injury. Metagenomic deep sequencing identified Candidatus M. haemohominis and determined its draft genome for an isolate from serum of the patient. A high copy number of the Candidatus M. haemohominis genome was detected in serum and bone marrow samples. Electron microscopy examination showed morphologic characteristics of Candidatus M. haemohominis. Levofloxacin monotherapy induced resistance caused by a gyrase A gene mutation in the quinolone resistance–determining region, but a combination treatment with moxifloxacin and minocycline was effective. We identified Candidatus M. haemohominis in a patient who had life-threatening symptoms related to multiple organ infection. Human infection with this mycoplasma might occur more frequently than has been generally recognized.
- Subjects :
- Adult
Male
Microbiology (medical)
Epidemiology
medicine.drug_class
lcsh:Medicine
medicine.disease_cause
Candidatus Mycoplasma haemohominis in Human, Japan
DNA gyrase
Deep sequencing
lcsh:Infectious and parasitic diseases
hemophagocytic syndrome
Mycoplasma
Japan
Moxifloxacin
Levofloxacin
medicine
Humans
lcsh:RC109-216
Mycoplasma Infections
bacteria
Skin
metagenomics
Candidatus Mycoplasma haemohominis
business.industry
Pruritus
lcsh:R
High-Throughput Nucleotide Sequencing
hemoplasma
Minocycline
biochemical phenomena, metabolism, and nutrition
Quinolone
Candidatus M. haemohominis
Virology
Microscopy, Electron
Infectious Diseases
Erythema
Synopsis
Candidatus
human infection
business
medicine.drug
Subjects
Details
- ISSN :
- 10806059 and 10806040
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Emerging Infectious Diseases
- Accession number :
- edsair.doi.dedup.....d690710383400b6fe9511125483aaba5