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Dietary tributyrin, an HDAC inhibitor, promotes muscle growth through enhanced terminal differentiation of satellite cells
- Source :
- Physiological Reports
- Publication Year :
- 2018
- Publisher :
- John Wiley and Sons Inc., 2018.
-
Abstract
- Muscle growth and repair rely on two main mechanisms – myonuclear accretion and subsequent protein accumulation. Altering the ability of muscle resident stem cells (satellite cells) to progress through their myogenic lineage can have a profound effect on lifetime muscle growth and repair. The use of the histone deacetylase (HDAC) inhibitor, butyrate, has had positive outcomes on the invitro promotion of satellite cell myogenesis. In animal models, the use of butyrate has had promising results in treating myopathic conditions as well as improving growth efficiency, but the impact of dietary butyrate on satellite cells and muscle growth has not been elucidated. We investigated the impact of tributyrin, a butyrate prodrug, on satellite cell activity and muscle growth in a piglet model. Satellite cells from tributyrin-treated piglets had altered myogenic potential, and piglets receiving tributyrin had a ~40% increase in DNA:protein ratio after 21days, indicating the potential for enhanced muscle growth. To assess muscle growth potential, piglets were supplemented tributyrin (0.5%) during either the neonatal phase (d1–d21) and/or the nursery phase (d21–d58) in a 2×2 factorial design. Piglets who received tributyrin during the neonatal phase had improved growth performance at the end of the study and had a ~10% larger loin eye area and muscle fiber cross-sectional area. Tributyrin treatment in the nursery phase alone did not have a significant effect on muscle growth or feed efficiency. These findings suggest that tributyrin is a potent promoter of muscle growth via altered satellite cell myogenesis.
- Subjects :
- 0301 basic medicine
tributyrin
Tributyrin
Skeletal Muscle
Satellite Cells, Skeletal Muscle
Physiology
Development and Regeneration
Swine
Cell
Muscle Fibers, Skeletal
Gene Expression
Butyrate
Muscle Development
Muscle hypertrophy
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
HDAC inhibitor
Physiology (medical)
satellite cell
medicine
Animals
myogenesi
Muscle, Skeletal
Triglycerides
Nutrition
Original Research
Myogenesis
Cell Differentiation
DNA
In vitro
Cell biology
Histone Deacetylase Inhibitors
030104 developmental biology
medicine.anatomical_structure
chemistry
Dietary Supplements
Female
Myogenin
Histone deacetylase
Cellular Physiology
myogenesis
Stem cell
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 2051817X
- Volume :
- 6
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Physiological Reports
- Accession number :
- edsair.doi.dedup.....d68c3512df76288a5db99f69a7aaf0c0