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Autoantibodies against Protein Phosphatase Magnesium-Dependent 1A as a Biomarker for Predicting Radiographic Progression in Ankylosing Spondylitis Treated with Anti-Tumor Necrosis Factor Agents
- Source :
- Journal of Clinical Medicine, Vol 9, Iss 3968, p 3968 (2020), Journal of Clinical Medicine, Volume 9, Issue 12
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Background: Patients with ankylosing spondylitis (AS) have increased levels of protein phosphatase magnesium-dependent 1A (PPM1A) and autoantibodies. We evaluated the usefulness of serum anti-PPM1A antibodies as a biomarker for AS. Methods: Serum samples from 58 AS patients were obtained from a multicenter registry prior to the initiation of anti-TNF agents. The serum levels of anti-PPM1A antibodies were measured using ELISA. Spinal radiographic progression was defined as an increase in the modified stoke ankylosing spondylitis spinal score (mSASSS) by &ge<br />2 units or a newly developed syndesmophyte. The role of exogenous PPM1A on bone mineralization was evaluated using primary osteoprogenitors acquired from patients with AS and non-inflammatory controls. Results: The baseline levels of anti-PPM1A antibodies and mSASSS were higher in the radiographic progression group than in the non-progression group. In logistic regression analysis, baseline mSASSS and serum anti-PPM1A antibodies were associated with a higher risk of progression. The level of anti-PPM1A antibodies for predicting progression had an AUC of 0.716 (cut-off value: 43.77 ng/mL). PPM1A stimulation increased matrix mineralization in AS-osteoprogenitors but not in controls. Conclusion: Along with mSASSS, the serum levels of anti-PPM1A antibodies might be useful as a predictor of radiographic progression after treatment with anti-TNF agents.
- Subjects :
- medicine.medical_specialty
Radiography
Phosphatase
lcsh:Medicine
Gastroenterology
Article
03 medical and health sciences
0302 clinical medicine
Internal medicine
ankylosing spondylitis
medicine
Anti tumor necrosis factor
030304 developmental biology
030203 arthritis & rheumatology
Syndesmophyte
0303 health sciences
Ankylosing spondylitis
biology
business.industry
lcsh:R
Autoantibody
biomarkers
General Medicine
medicine.disease
protein phosphatase magnesium-dependent 1 A
radiographic progression
biology.protein
Biomarker (medicine)
Antibody
business
autoantibody
Subjects
Details
- Language :
- English
- ISSN :
- 20770383
- Volume :
- 9
- Issue :
- 3968
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Medicine
- Accession number :
- edsair.doi.dedup.....d687462454dde2fa29e4ae562b7b3550