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Medicinal Plants for the Treatment of Mental Diseases in Pregnancy: An In Vitro Safety Assessment
- Source :
- Planta medica. 88(12)
- Publication Year :
- 2021
-
Abstract
- Pregnancy is a critical period for medical care, during which the well-being of woman and fetus must be considered. This is particularly relevant in managing non-psychotic mental disorders since treatment with central nervous system-active drugs and untreated NMDs may have negative effects. Some well-known herbal preparations (phytopharmaceuticals), including St. Johnʼs wort, California poppy, valerian, lavender, and hops, possess antidepressant, sedative, anxiolytic, or antidepressant properties and could be used to treat mental diseases such as depression, restlessness, and anxiety in pregnancy. Our goal was to assess their safety in vitro, focusing on cytotoxicity, induction of apoptosis, genotoxicity, and effects on metabolic properties and differentiation in cells widely used as a placental cell model (BeWo b30 placenta choriocarcinoma cells). The lavender essential oil was inconspicuous in all experiments and showed no detrimental effects. At low-to-high concentrations, no extract markedly affected the chosen safety parameters. At an artificially high concentration of 100 µg/mL, extracts from St. Johnʼs wort, California poppy, valerian, and hops had minimal cytotoxic effects. None of the extracts resulted in genotoxic effects or altered glucose consumption or lactate production, nor did they induce or inhibit BeWo b30 cell differentiation. This study suggests that all tested preparations from St. Johnʼs wort, California poppy, valerian, lavender, and hops, in concentrations up to 30 µg/mL, do not possess any cytotoxic or genotoxic potential and do not compromise placental cell viability, metabolic activity, and differentiation. Empirical and clinical studies during pregnancy are needed to support these in vitro data.
- Subjects :
- Valerian
medicine.drug_class
Placenta
Pharmaceutical Science
Pharmacology
medicine.disease_cause
Anxiolytic
Analytical Chemistry
law.invention
03 medical and health sciences
0302 clinical medicine
law
Pregnancy
Drug Discovery
medicine
Oils, Volatile
Humans
Hypnotics and Sedatives
Medicinal plants
Essential oil
030304 developmental biology
0303 health sciences
Plants, Medicinal
biology
business.industry
Plant Extracts
Mental Disorders
Organic Chemistry
Hypericum perforatum
biology.organism_classification
medicine.disease
Antidepressive Agents
3. Good health
Glucose
Complementary and alternative medicine
Anti-Anxiety Agents
030220 oncology & carcinogenesis
Toxicity
Lactates
Molecular Medicine
Female
business
Genotoxicity
Hypericum
Phytotherapy
Subjects
Details
- ISSN :
- 14390221
- Volume :
- 88
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Planta medica
- Accession number :
- edsair.doi.dedup.....d67af0f4cfedd2970f6741589899b4d5