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Current therapeutic options for low‐risk papillary thyroid carcinoma: Scoping evidence review

Authors :
Avi Khafif
Luiz Paulo Kowalski
Jesus E. Medina
Dana M. Hartl
Ralph P. Tufano
Alessandra Rinaldo
Gregory W. Randolph
Alfio Ferlito
Mark Zafereo
Pilar Pinillos
Vincent Vander Poorten
R. Simo
Antti Mäkitie
Renan Bezerra Lira
Jatin P. Shah
Juan P. Rodrigo
Ashok R. Shaha
Alvaro Sanabria
Peter Angelos
Iain J. Nixon
Source :
Head & Neck. 44:226-237
Publication Year :
2021
Publisher :
Wiley, 2021.

Abstract

Most cases of thyroid carcinoma are classified as low risk. These lesions have been treated with open surgery, remote access thyroidectomy, active surveillance, and percutaneous ablation. However, there is lack of consensus and clear indications for a specific treatment selection. The objective of this study is to review the literature regarding the indications for management selection for low-risk carcinomas. Systematic review exploring inclusion and exclusion criteria used to select patients with low-risk carcinomas for treatment approaches. The search found 69 studies. The inclusion criteria most reported were nodule diameter and histopathological confirmation of the tumor type. The most common exclusions were lymph node metastasis and extra-thyroidal extension. There was significant heterogeneity among inclusion and exclusion criteria according to the analyzed therapeutic approach. Alternative therapeutic approaches in low-risk carcinomas can be cautiously considered. Open thyroidectomy remains the standard treatment against which all other approaches must be compared.

Details

ISSN :
10970347 and 10433074
Volume :
44
Database :
OpenAIRE
Journal :
Head & Neck
Accession number :
edsair.doi.dedup.....d670250a2147f465c370b4744623b4ab
Full Text :
https://doi.org/10.1002/hed.26883