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Establishment and Validation of a Nomogram for Nasopharyngeal Carcinoma Patients Concerning the Prognostic Effect of Parotid Lymph Node Metastases
- Source :
- Cancer Research and Treatment : Official Journal of Korean Cancer Association
- Publication Year :
- 2020
- Publisher :
- Korean Cancer Association, 2020.
-
Abstract
- Purpose The prognosis of nasopharyngeal carcinoma (NPC) patients with parotid lymph node (PLN) metastasis remains unclear. This study was performed to investigate the prognostic significance and optimal staging category of PLN metastasis and develop a nomogram for estimating individual risk.Materials and MethodsClinical data of 7,084 non-metastatic NPC patients were retrospectively reviewed. Overall survival (OS) was the primary endpoint. A nomogram was established based on the Cox proportional hazards regression model. The accuracy and calibration ability of this nomogram was evaluated by C-index and calibration curves with bootstrap validation.ResultTotally, 164/7,084 NPC patients (2.3%) presented with PLNs. Multivariate analyses showed that PLN metastasis was a negative prognostic factor for OS, progression-free survival (PFS), distant metastasis-free survival (DMFS), and locoregional relapse-free survival (LRFS). Patients with PLN metastasis had a worse prognosis than N3 disease. Five independent prognostic factors were included in the nomogram, which showed a C-index of 0.743. The calibration curves for probability of 3- and 5-year OS indicated satisfactory agreement between nomogram-based prediction and actual observation. All results were confirmed in the validation cohort.ConclusionNPC patient with PLN metastasis had poorer survival outcome (OS, PFS, DMFS, and LRFS) than N3 disease. We developed a nomogram to provide individual prediction of OS for patients with PLN metastasis.
- Subjects :
- Oncology
Male
Cancer Research
medicine.medical_specialty
Multivariate analysis
medicine.medical_treatment
Nomogram
Metastasis
Internal medicine
medicine
Clinical endpoint
Overall survival
Humans
Retrospective Studies
Nasopharyngeal Carcinoma
Radiotherapy
business.industry
Parotid lymph node
Nasopharyngeal Neoplasms
Middle Aged
medicine.disease
Prognosis
Combined Modality Therapy
Parotid Neoplasms
Radiation therapy
Survival Rate
Nomograms
Nasopharyngeal carcinoma
Lymphatic Metastasis
Parotid lymph node metastasis
Original Article
Female
Lymph Nodes
Neoplasm Recurrence, Local
business
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 20059256 and 15982998
- Volume :
- 52
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Cancer Research and Treatment : Official Journal of Korean Cancer Association
- Accession number :
- edsair.doi.dedup.....d66e2e9b78c68c67919c8ffc0da55c50